"Comfort Zone" wherever you drive, test drive Haval’s second-generation big dog Hi4 version

To be honest, when I saw Haval for the first time, I didn’t feel good-looking, and even felt a little stunned. It may be that the Great Wall took into account the elements of tanks and market positioning, so it moderately recovered the impression that Haval should be tougher. At most, the exposed rivets on the eyebrows are very eye-catching. Therefore, Haval’s second-generation big dog has obviously learned from experience, and the overall design is more mature and textured. The headlights are no longer just for the front. Under the contours of many car manufacturers have given square boxes, Haval’s second-generation big dog has changed to plump muscle lines throughout the body. I personally think it looks much better

The test drive route starts from the urban area. Sitting in the driver’s seat, I can’t help but take a look at this new interior first. Basically, there are mainstream elements at the moment, such as 12.3-inch full LCD meters, 14.6-inch floating central control screen, and passenger armrests. Using the latest generation of coffee intelligent cockpit systems, the sense of technology and off-road style is quite strong. With a three-spoke multi-function steering wheel and electronic gear bar, as well as many physical buttons, the practicality is also impossible to find fault with. Even the interior is basically covered with soft materials, and even the armrests in front of the passenger are soft. This is really rare.

And there are basically no faults in the configuration. The L2 level driver assistance system, electric induction trunk, HUD head-up display, wireless charging of the front mobile phone, multi-directional electric adjustment and heating of the front seat, memory of the main driver’s seat, 10-speaker sound, automatic folding of the outer rearview mirror lock car, automatic anti-dazzling inner rearview mirror and other functions are also available. I even found the camping mosquito repellent lamp that comes with the car next to the passenger. This thing has 5 light modes, and it also has a magnetic suction design, which is convenient for you to attach to the body. More importantly, it is also a mosquito repellent lamp, which helps the owner think of the needs when camping.

As for the performance in space, Haval’s second-generation big dog has a length, width and height of 4705 * 1908 * 1780mm, a wheelbase of 2810mm. Under the long-axis and short-suspension design, it has a shaft-length ratio of 0.597, a room gain rate of 62.6%, and a trunk volume of 483L to a maximum of 1362L. It can also find more storage space than other competing products everywhere, such as a separate beverage storage slot on the door, and an elastic belt is also used to fix it, which is quite attitude.

It doesn’t seem necessary to buy an electric SUV.

Pressing the engine start button, I forgot for a while that this Haval second-generation big dog was a PHEV, and I pressed it several times. I expected it to be accompanied by a sound wave after starting, but after failing, I was not disappointed. For me, who has tested too many hard-line SUVs in the past, this quiet environment may still be a little uncomfortable in such a masculine SUV.

But after the start of the feeling, my mood changed, I don’t know why, the first impression in my mind is actually Prado, not because the second generation of Haval big dog is better, but that the Prado, which is worth several times more, may not reach such a mobile experience.

But I fully agree with the brand value. It is an intangible value other than the product itself, representing historical accumulation, more user reputation, etc. But if you are not too interested in these, buying a Haval second-generation big dog is really enough.

Because the Haval second-generation big dog Hi4 version at low speed is powered by pure electricity when fully charged, you can also hear quite obvious pedestrian warnings. During urban driving, the vehicle is mainly driven by the rear motor. Only when accelerating or overtaking, the vehicle will switch to four-wheel drive mode. This acceleration process is basically the same as that of an electric vehicle. It is quiet but low-twist, and the weight of the body is invisible. It can achieve 0-100km/h acceleration of 6.3 seconds at the fastest. This is based on traditional fuel power in the past. I think even 3.0T is difficult to achieve the same performance. However, the main fuel engine of the Haval second-generation big dog Hi4 version is only 1.5T.

And Hi4 technology has a total of 3 power modes and 9 working modes. Its structure includes a two-in-one arrangement of front axle motors, which can both generate electricity and drive, with a maximum power of 70kW and a maximum torque of 160N · m. The rear drive module assembly directly drives the rear wheels, forming a 50:50 ratio with the front axle, a maximum power of 150kW and a maximum torque of 350N · m, so that the overall system has a comprehensive power of 278kW and a comprehensive torque of 750N · m. This layout also abandons the traditional axle, not only does it lack the existence of a fragile part (if it is often used off-road), but the center of the rear baseplate finally does not need to see that annoying bulge.

So before arriving at today’s off-road experience venue, Haval’s second-generation big dog Hi4 version has a certain off-road performance, but the feeling of driving it is obviously to seize the original owners who are used to city SUVs. The appearance looks tough, but in fact it is as easy to drive as a car. The light power response is one thing. The quiet of the Haval second-generation big dog Hi4 version is really good. The speed has to reach 120km/h to hear the wind cutting sound. I also think that the level of NVH is comparable to that of a car. In addition to the seats being very thick and soft, the rear windows are even arranged with manual sunshades. This design can make many MPVs feel embarrassed.

The other place you don’t want to face is the "comfort zone"?

In fact, I have always believed that the new car with excellent off-road performance does not make much sense, after all, it will be accompanied by the high price of the car to make the owner reluctant, but it is the second generation of Haval big dog, even if the top match does not exceed 200,000 car, in the car cycle can really participate in the outdoor off-road practice probability.

So this is also one of the reasons why Haval’s second-generation big dog joined Hi4 technology. After all, high fuel consumption has always been a flaw in off-road SUVs. It is not about the fuel money, but to really plan a long-distance crossing trip. You don’t need to modify a secondary fuel tank.

Of course, Haval’s second-generation big dog Hi4 version is only advertised as "3/4 scale light off-road" in the original factory, but after an afternoon of actual experience, I think it is enough to meet the needs of 95% of users for self-driving in the suburbs.

Because in the final analysis, it is still inseparable from this new set of intelligent four-wheel drive electric hybrid technology Hi4, so even if the traditional three-lock structure is missing, you can also achieve the same effect by distributing the output of the front and rear axle motors, which is the existence value of this iTVC intelligent torque vector control system. In fact, it is not too complicated to think about. When the system detects that the wheels are slipping or suspended, you don’t have to worry about too much power being distributed to the wheels and idling meaningless. The motor can be fully attached to the wheel for escape, which is also the reason why electric SUVs can make a U-turn in place, while traditional fuel vehicles cannot do it for a lifetime.

In addition, the motor has the characteristics of instantaneous high torsion output, so even if it is deep in the shell crater and other terrain, it can easily get out of trouble. After all, it has a design with an approach angle of 24 °, a departure angle of 30 °, and a minimum ground clearance of 200mm. And fuel vehicles may only be solved by means of large-displacement engines in a hard-on way. Therefore, the solution used by Haval’s second-generation big dog Hi4 version to interpret off-road is undoubtedly more like the principle of "four or two thousand gold". Any energy released in the wheels and moving forward is basically not wasted. Many times, the intervention of the engine is the icing on the cake, and the sound of running on the steep slope can also give people an impression of being polite.

And many campsites are also equipped with charging stations. If the owner wants to release the off-road performance of Haval’s second-generation big dog Hi4 version more perfectly, it is recommended to drink a cup of coffee and charge it. You can have a 102km NEDC pure electric cruising range, allowing the vehicle to achieve a WLTC comprehensive fuel consumption of 1.83L/100km. When you arrive at the camp, you can also use the V2L external discharge function. When fully charged, you can discharge electricity for 30 hours. One night in the field is enough.

Write after the text:

Haval’s second-generation Big Dog Hi4 version allows users to indulge in the wild at a lower cost, not only allowing more users to "afford" four-wheel drive off-road SUVs, Haval Big Dog has inherited more than 30 years of SUV manufacturing experience, and the products can also stand the test in terms of quality and reputation. After driving it once, it is really difficult not to be planted by it.

Project Fanxing focuses on "pulse-taking", "consultation" of cases, and evaluation of development and reform cases. ……

Original Shenguanban Liu Peng Shashi District People’s Court

What is the problem with the development and reform case? How to grasp the unified standard of referee? How to improve the quality and effectiveness of cases? Thereby enhancing judicial credibility? On September 19th, the 6th issue of "Shafa Lecture Hall" of the "Stars Project" of Shashi District People’s Court started as scheduled. The theme of this issue focused on the development and reform cases in our hospital this year, analyzed and judged the overall operation of the development and reform cases, and comprehensively discussed the difficulties and blocking points in the development and reform cases. Judges and assistant judges of all posts will attend the meeting.

During the activity, 10 members of the Judicial Committee took the stage to speak in turn according to their respective evaluations. With their profound legal knowledge and rich trial experience, they analyzed the trial procedure, fact finding and legal application of the case in depth, accurately pointed out the problems existing in the trial of the case, and made sharp and concise language, and put forward targeted suggestions on how to improve the quality of the case.

Wang Xi, deputy secretary and vice president of the Party Group, said that the evaluation of the reform cases is not only a "physical examination" of the cases that have been reformed, but also a "alignment" of the superior courts in the application of similar laws and the direction of adjudication, so as to keep the judgment scale and handling methods of our court consistent with those of the superior courts and reduce the number of cases that have been reformed.

Wang Zhonghua, party secretary and president of the hospital, stressed that the quality of cases is the lifeline of trial work, and the development and reform of cases is a key indicator to measure the quality of cases and the satisfaction of the masses. The hospital should adhere to the problem orientation, deeply analyze the causes of development and reform, and respond to the new expectations of the people with new results in trial work. First, adhere to the problem orientation. It is necessary to seriously reflect on the reasons for the reform, learn lessons from each case, accumulate experience for future trial work, and improve the ability to resolve disputes. The second is to improve business standards. "Sharpening the knife does not mistake the woodcutter". It is necessary to make good use of the auxiliary tools for handling cases, such as the live answer network, case base and case retrieval, and through extensive access to relevant documents and materials, strengthen the understanding of the legislative intent, improve the level of identifying legal facts, improve the quality of cases, and reduce the number of cases that have been changed. The third is to compact the regulatory responsibility. The president of the hospital should give full play to the responsibility of trial supervision and management, strictly implement the supervision of "four types of cases" and the review of cases, and strictly control the quality. It is necessary to give full play to the role of professional judges’ meetings and trial committees in summing up trial experience and unifying judgment standards, so as to improve the overall quality of cases.

Original title: "The Stars Project focuses on" pulse-taking ",case" consultation ",and the case of development and reform is being commented …"

What is the importance of the "Olympic House" trophy given by President Bach to the Director of the General Desk?

Source: media headlines

  According to CCTV news reports, on May 6th, IOC President Bach paid a visit to the Central Radio and Television General Station, and had in-depth exchanges with Vice Minister Publicity Department of the Communist Party of China and Director of the Central Radio and Television General Station Shen Haixiong on topics such as Olympic broadcast reports, research and application of new technologies, and the spread of Olympic culture. Xing Bo, deputy director of the General Desk, Yu Zaiqing, Li Lingwei and Zhang Hong, members of the International Olympic Committee, Xue Jijun and Fan Yun, members of the editorial board of the General Desk, accompanied the tour. The two sides also witnessed the signing ceremony of the invitation of CCTV to become the main broadcaster of the Paris Olympic Games.

  Bach said that he was very happy to meet his old friends here. China Central Radio and Television General Station has made record achievements in Olympic communication, especially in the coverage of Beijing Winter Olympics, which has set new standards and set new records in terms of audience number, new technology use and signal production, and won five consecutive "Olympic Golden Ring Awards" from the International Olympic Committee, demonstrating the infinite charm of the Olympic movement and proving the international leading sports communication strength of General Station. With the past success, there is more reason to believe that the cooperation between the IOC and the Headquarters will make greater progress in the future.

  Shen Haixiong said that the Olympic spirit and its motto of "more unity" are similar to the concept of the community of human destiny put forward by the Supreme Leader Chairman, and are also highly consistent with the international communication goal of the General Station. The Headquarters is willing to work with the International Olympic Committee to continue to deepen cooperation in accelerating technological innovation, developing e-sports events, building an Olympic channel, attracting young audiences, and spreading the Olympic movement and culture, so as to spread the Olympic spirit in a never-ending pace and make new and greater contributions to building a community of human destiny.

  After the visit, Shen Haixiong presented Bach with a video collection recording the friendly exchanges between the two sides, a series of excellent programs of the reception desk, and philatelic products commemorating the fifth anniversary of the establishment of the reception desk.When presenting Shen Haixiong with the autographed "Olympic House" trophy symbolizing unity and friendship, Bach said affectionately: "This is the Olympic House and your home!" Shen Haixiong said: "The reception desk is also the home of the Olympians. We will continue to work together to carry forward the Olympic spirit!"

  What’s the point of this trophy presented by President Bach to the director of the reception desk? According to the relevant information of the International Olympic Committee, the "Olympic House" trophy presented by President Bach to the Director of the General Desk is made of marble and is decorated with copper alloy double rings. It is simple, dignified and smart. It is a high-standard trophy specially made for the President of the International Olympic Committee and given to specific VIPs to reward international people who have played an important role in the Olympic Movement.

  According to reports, the trophy was designed and produced by Rosa Serra, a Spanish national treasure sculptor known as "contemporary Michelangelo", and the base was autographed by the current International Olympic Committee President Bach. The trophy is based on the prototype of the ioc headquarters Building "Olympic House" in Lausanne, Switzerland. The building is shaped like a dove of peace, symbolizing peace and friendship, and it is one of the most important messages transmitted by the Olympic Movement. It is reported that the "Olympic House" building was officially opened on June 23, 2019, International Olympic Day.

  According to the official report of the International Olympic Committee, the trophy was presented to South Korean Zhao Zhengyuan, the current president of the World Taekwondo Federation, in December 2022. This time, President Bach awarded this trophy to the director of the reception desk, which is also the first time that this trophy has been spent in China.

  Chief Producer Yang Hua Dou Xiaowen

  Prison system-Xu Chaoqing

  Editor-in-Chief Hu Sister-in-law Zhang Yadong

  Editing Zhang Siqi Sun Jiatong

Improve the efficiency of supervision and escort the high-quality development of cultural tourism.

In the past ten years, Zhangye’s culture and tourism industry has always adhered to the people-centered development thought, taking market supervision as the premise and foundation of the development of the cultural tourism industry, further improving the safety working mechanism, focusing on building a safety responsibility system, taking "quality tourism" as the guide and "tourists’ satisfaction" as the goal, actively building a "pilot city for the development of credit economy in the cultural and tourism market" and a "zero complaints and zero accidents" tourist city in the northwest, thus creating a healthy and harmonious society.

First, improve the new mechanism to promote safety production and epidemic prevention and control.

Issued the "Implementation Opinions on Fully Implementing the Territorial Management Responsibility of Safety Production in the Cultural and Tourism Industries" and made efforts to build a cultural tourism safety responsibility system. For special areas such as tourist chartered cars and high-risk tourism projects, we will jointly carry out law enforcement inspections with departments such as transportation, market supervision and fire protection, and establish a departmental linkage mechanism; Joint meteorological departments to establish a "tourism safety+meteorology" linkage and coordination mechanism to further strengthen safety capacity building. Adhere to the preparations for the "Eleventh" and "Spring Festival" Golden Week and other holiday tourism as an important task, hold special meetings at different levels to mobilize and deploy, and conduct centralized investigations on the safety of key links to ensure the safety of holiday tourism. In the past ten years, there has not been a safety accident in the cultural tourism industry. Since the outbreak of the epidemic in COVID-19, we have persisted in carrying out continuous net-pulling, high-density, uninterrupted and full-coverage inspections on the business premises of cultural tourism in municipal districts, collecting information of employees in time, finding out the base of epidemic prevention and control, and establishing key population accounts of key institutions of cultural tourism industry in Zhangye City to ensure that the epidemic does not spread in the cultural tourism industry of the whole city. During several epidemics, he showed humanistic care, presented more than 700 tourists stranded in other places with Zhangye travel postcards, and could visit 4A-level scenic spots in the city for unlimited times without tickets within one year.

Second, open a new model to further stimulate the vitality of market players.

Successfully established a national tourism standardization demonstration city, and actively played the demonstration effect of 100 cultural and tourism standardization enterprises in 19 categories, including urban tourist distribution centers, travel agencies, tourist attractions, red tourism classic scenic spots and tourist resorts. In the past ten years, the market players have been continuously cultivated and expanded. The number of head offices of travel agencies has increased from 15 in 2012 to 93, and the number of star-rated hotels has increased from 14 in 2012 to 52 (including 1 gold-leaf green hotel and 9 silver-leaf green hotels). Earnestly implement the policies and measures to help enterprises tide over the difficulties, and temporarily refund the deposit of tourism service quality of 11.2 million yuan, in order to reduce the burden on travel agencies and help enterprises tide over the difficulties.

Third, build new carriers and further improve service quality

Focusing on the theme of "What to do in the cultural tourism industry and how to do it for employees", since 2012, more than 800 training sessions have been held in star-rated hotels, travel agencies, tourist attractions, rural tourism, tour guides, administrative law enforcement, etc., with more than 60,000 participants and 20 service skill competitions. Huachen International Hotel in Zhangye City has won the first prizes of groups and individuals in the service skill competition of star-rated hotels in the province for many times. In the competition, Liu Huiyuan, the "sister who made the bed in Zhangye", became popular with 26 million hits, which fully demonstrated the excellent professional quality and spiritual outlook of tourism professionals. In combination with the creation of a national civilized city, we will carry out in-depth "double advocacy and double guidance" activities with the theme of advocating civilized tourism, persuading uncivilized behavior, advocating environmental protection and persuading ugly habits, establish a joint conference system of civilized tourism in Zhangye City, led by the Municipal Wenguang Tourism Bureau and the Municipal Civilization Office, with 10 relevant municipal departments as members, and post and distribute more than 50,000 copies of civilized tourism materials in railway stations, airports, high-speed railway station and tourist distribution centers, creating a strong propaganda atmosphere for civilized tourism.

Four, promote new reforms, and further enhance the effectiveness of comprehensive law enforcement.

In combination with institutional reform, the Zhangye Cultural Market Comprehensive Administrative Law Enforcement Team was established by integrating the former Municipal Cultural Market Comprehensive Law Enforcement Detachment and the former Municipal Tourism Law Enforcement Detachment, so as to uniformly exercise administrative law enforcement duties in six major areas: culture and art, radio and television, film, printing and publishing (copyright), cultural relics and tourism. We have carried out more than 60 special actions, such as "ultimate revenge", "eliminating pornography and illegal publications", renovating cultural markets around campus, renovating script entertainment venues, renovating unlicensed entertainment venues, operating travel agency business without permission, renovating unreasonable low-cost tours, cracking down on pension fraud, purifying the art market environment, and renovating privately-run scenic spots. The city and county levels have dispatched 37,595 law enforcement personnel, inspected 13,200 business units of various cultural tourism markets, and completed the administration. Received, investigated and handled 110 complaints from tourists every year, the settlement rate reached 100%, and the mediation success rate reached 100%. Two major tourist complaints were properly and efficiently handled, and the stranded tourists were given the banner of "impartially enforcing the law and doing practical things, helping each other wholeheartedly and warming people’s hearts", which effectively maintained Zhangye’s tourism image and improved tourists’ satisfaction.

Source: Zhangye Municipal Bureau of Culture, Radio, Film and Tourism

Editor: Lu Bohan

Audit: Zhuo Lingrui

Reporting/feedback

US aircraft carrier goes to the Middle East, and Iran’s "carrier killer" attracts attention.

  Reference News Network reported on May 13 The Associated Press reported on May 7 that US Acting Defense Minister Shanahan confirmed to reporters at the Pentagon on the 7 th that he had approved the accelerated dispatch of the "Lincoln" aircraft carrier battle group to the Middle East. US Presidential National Security Assistant Bolton said that sending an aircraft carrier battle group to the Middle East is an "unequivocal" signal to Iran. And how many cards can Iran, which is regarded as an "imaginary enemy" by the former, play when facing the US aircraft carrier?

  For a long time, Iran has been promoting its "anti-aircraft carrier" combat power. In all kinds of official propaganda videos, there are not only speedboats "wolves" besieging aircraft carriers, but also rocket launchers shooting at aircraft carriers, and even "single-handedly fighting aircraft carriers" highlighting "will conquers technology".However, the anti-aircraft carrier equipment that Iran relies most on and the United States attaches most importance to is the "Iranian version of the aircraft carrier killer" — — Persian Gulf and Hormuz anti-ship ballistic missiles.

  According to the British "Jane’s Defense Weekly" report, the "Persian Gulf" missile is said to be improved from the "Conqueror -110" missile. It is Iran’s first anti-ship ballistic missile and was first exposed in 2011. In the test picture released by Iran, the missile hit a stationary target ship. The "Hormuz" anti-ship ballistic missile is considered to be an improved version of the "Persian Gulf" missile (with active radar guidance head), which made its debut in 2014.

  According to Lebanon’s "Arab Motherland" newspaper, in the military exercise in early 2015, Iran successfully hit a 60-meter-long maritime moving target with the Persian Gulf missile. According to the Iranian Tasneem News Agency, in early 2017, the Iranian Revolutionary Guards test-fired the "Hormuz" missile and successfully hit a floating target 150 kilometers away. Iran’s official media commented that Iran hit a maritime target much smaller than the aircraft carrier with a completely self-made ballistic missile, so it can be concluded that the "aircraft carrier myth" has ended.

  However, the United States has always had doubts about the actual combat power of the Iranian version of the "aircraft carrier killer." A report released by the Center for Strategic and International Studies in August 2014 questioned the statement that "Iran can effectively use the anti-ship ballistic missile system". The think tank believes that Iran lacks the sensors and communication infrastructure needed to ensure targeting. Even ballistic missiles with terminal guidance capabilities need the support of intelligence, surveillance and reconnaissance systems. If an attack is launched "rudely" on the area suspected of American ship activity, Iran may not have enough missiles available. In addition, according to the speed characteristics of Iran’s anti-ship ballistic missile, it is also difficult for it to break through the Aegis missile defense system.

  However, considering the geographical location of the Strait of Hormuz and Iran’s progress in reconnaissance and surveillance capabilities in recent years, Iran’s anti-ship ballistic missiles are still the most troublesome presence in the Middle East for American aircraft carriers. Especially in recent years, the construction and application of Iran’s UAV fleet not only enriches its anti-intervention arsenal, but also partially makes up for its shortcomings in reconnaissance and surveillance. For example, in March this year, the Iranian Revolutionary Guards released video clips of 50 attack drones attacking island targets for about 1,000 kilometers. In April, the Iranian Revolutionary Guards also released a set of high-definition videos, recording the process of Iranian drones "observing" the formation of American aircraft carriers at close range. These "aircraft carrier killers" at least ensure that Iran maintains "the power to fight back" when facing the US aircraft carrier.

The United States has repeatedly issued "three arrows" to the DPRK. South Korea: The United States has exerted "maximum pressure" on the DPRK.

  Cctv newsRecently, the Trump administration of the United States has repeatedly issued "three arrows" and frequently put pressure on North Korea. The situation on the peninsula, which has been calm for several weeks, is facing the risk of falling into "circular confrontation" again. Let’s see which "three arrows" the United States has shot at North Korea.

  "First Arrow": Diplomatic isolation. On the 20th of this month, the DPRK was reclassified into the list of "countries supporting terrorism"; This is nine years later, the United States once again labeled North Korea as a "state sponsor of terrorism".

  "Second Arrow": Economic sanctions. On the 21st of this month, the US Treasury Department imposed sanctions on a number of North Korean enterprises, ships and individuals, further cutting off the source of funds for North Korea’s nuclear research and development.

  "The Third Arrow": Military deterrence. On the 24th of this month, Yonhap News Agency quoted the South Korean Ministry of National Defense as saying that the United States and South Korea will launch a joint military exercise of "Watch out for Ace" from December 4th to 8th. For the first time, the US military sent six F-22 Raptors, which are known as the world’s strongest stealth fighters, to participate.

  US F-22 and F-35 or a joint military exercise in the United States and South Korea.

  At the beginning of next month, six F-22 Raptors will join the F-35 stealth fighters in the joint military exercise between South Korea and the United States. After dispatching three aircraft carriers at the same time, the US military made another big move.

  Korean media said that if the US F-22 set off from Wushan Air Force Base in South Korea, it could "break through" the dense North Korean radar network and penetrate into Pyongyang’s airspace in just seven minutes.

  Korean media: It is the first time that two state-of-the-art fighters have participated in the show at the same time.

  TV North Korea TV station commented that it is the first time that the F-22 and another advanced stealth fighter F-35 of the US military simultaneously attacked the Korean peninsula to participate in the joint military exercise between the United States and South Korea.

  F-35 fighter is the fifth generation multi-purpose combat aircraft developed by the United States and some allies. It is equipped with new avionics and has radar stealth capability. The F-35 is divided into three versions: A, B and C, which are conventional take-off and landing type, short take-off and vertical landing type and aircraft carrier take-off and landing type, and are used by the Air Force, Marine Corps and Navy. On the 18th of this month, the F-35 fighter planes of the US Marine Corps flew to the Iwakuni base of the US military stationed in Japan to start deployment. This is the first time that the United States has deployed this model outside the mainland, with a total of 16 aircraft deployed.

  The F-22 Raptor is claimed to be the strongest stealth fighter in the world. F-22 "Raptor", by Lockheed? Developed by Martin, the fuselage length is 18.9 meters, the wingspan is 13.56 meters, the cruising speed is 1960 km/h, and the top speed can reach 2410 km/h. The remarkable advantage of F-22 lies in its powerful "four super" capability — — Super stealth, supersonic cruise, super maneuverability, and over-the-horizon strike. Among them, the super stealth ability is the key to the F-22′ s ability to haunt and become a "battlefield raptor".

  From fighter planes to aircraft carriers, the United States continues to put pressure on North Korea.

  According to Yonhap News Agency, the US F-22 and F-35 fighter formations are believed to be participating in exercises such as "enemy infiltration" and "precision strike" together with Korean fighters in this joint military exercise of "vigilance ace". South Korean officials said that the US move is intended to exert "maximum pressure" on North Korea.

  Since the beginning of this year, the situation on the Korean peninsula has suddenly become tense. The United States has sent advanced fighter planes such as B-1B, F-35B and F-22 to the peninsula in turn to send a shocking signal. In addition to the strengthening of the air force, the US aircraft carrier fleet is also strengthening its deployment in the western Pacific. From 11th to 14th of this month, three US aircraft carrier strike groups held a military exercise in the western Pacific. This military exercise was the first gathering of three aircraft carrier strike groups since they participated in the exercise in the waters near Guam in 2007.

There is no doubt that Putin will be re-elected

Reporter | Chen Bing

  On the occasion of Chinese New Year in the Year of the Loong, Russians are busy preparing for the general election from March 15th to 17th, which will be the first highlight of the global "super election year" in 2024.

  According to the Global Times, the Russian Central Election Commission announced the list of candidates for the presidential election on February 8. In addition to Putin, the other three candidates are Russian Duma Vice Chairman Da Vankov, Liberal Democratic Party leader slutsky and communist party candidate Harry Tonov.

  According to a poll conducted by the Russian Public Opinion Research Center, 62% of the respondents said they would definitely vote, 14% said they might vote, 4% said they might not vote, and 7% said they would definitely not vote.

  The poll was conducted by telephone interview on February 8, and a total of 1,600 Russian citizens over the age of 18 were surveyed. Among the respondents who intend to vote, 75% said they would support Putin in the general election, 5% said they would support Vladislav da Vankov, the candidate of the New Party, Nikola Khaled Tonov, the candidate of the Russian Communist Party, and Leonid slutsky, the candidate of the Liberal Democratic Party, tied for third place with 4% support rate. The results of the latest polls show that the number of people who support Putin’s re-election this time is very close to the 76.69% vote rate of Putin in the latest 2018 general election.

  As a world-class power that ranks among the "five permanent members" of the United Nations, holds a powerful nuclear arsenal, vast resources and global political influence, Russia, which has experienced two years of Russian-Ukrainian conflict, has become a hot topic of global concern at the juncture of this general election.

Above: On February 12, 2024, Russian President Vladimir Putin presided over the Russian Economic Work Conference.

Who is singing "Against Taiwan" with Putin?


  Compare the four candidates who participated in the Russian presidential election-in terms of age, Harry Tonov is the oldest, 75 years old; The youngest is da Vankov, who has just turned 40. In terms of academic qualifications, all four candidates have received higher education. Putin and Harry Tonov are associate doctors in economics (equivalent to Dr. China), da Vankov is associate doctor in sociology, and slutsky is doctor in economics (equivalent to postdoctoral fellow in China).

  In terms of election experience, two of the four presidential candidates have participated in the presidential election. Putin participated in the presidential election four times, and Harry Tonov participated in a presidential election in 2004. Slutsky and da Vankov ran for the first time this year.

  In terms of duties, except Russian President Vladimir Putin, the other three candidates are all members of the State Duma (lower house of parliament), Da Vankov is the vice chairman of the State Duma, slutsky is the chairman of the State Duma International Affairs Committee, and Harry Tonov is the chairman of the State Duma Far East and Arctic Development Committee.

  In terms of property, according to the income information submitted by four people from 2017 to 2023, Da Vankov earned the most. His income in six years was about 76.91 million rubles (about 5.945 million yuan), and his wife earned 810,000 rubles (about 62,000 yuan). Slutsky has the lowest income, with an income of about 35.98 million rubles (about 2.78 million yuan) and his wife’s income of 29.16 million rubles (about 2.25 million yuan). Putin has the largest deposit, about 54.41 million rubles (about 4.205 million yuan), and slutsky has the least deposit, with only 1,285 rubles (about 990,000 yuan). However, slutsky has the most real estate, with 7 properties; Putin has the least real estate, only an apartment and a parking space in St. Petersburg.

  Apart from Putin who registered for the election by self-nomination, who are the other three-Da Vankov, slutsky and Harry Tonov?

  Gou Liwu, an assistant professor at the School of Marxism of Tongji University and a young researcher at the Russian Research Center of East China Normal University, the key research base of humanities and social sciences of the Ministry of Education, told Xinmin Weekly that Vladislav da Vankov was born in Smolensk in 1984 and was the youngest of the four presidential candidates. Da Vankov graduated from Moscow University in 2006, joined nechayev’s company in the same year, and was promoted to vice president in 2013. In 2020, nechayev founded the New Party, and appointed Da Vankov as the chairman of the Central Executive Committee. In 2021, he was elected as a member of the Russian Duma, and Duma Chairman Volodin appointed Da Vankov as the vice chairman of the Duma. Da Vankov is a rare moderate opposition. During the COVID-19 epidemic, it opposed compulsory vaccination. In the Russian vote to recognize the independence of Donetsk and Lugansk, the New Party was the only party that abstained. In addition, da Vankov also supported the candidacy of Najreddin, a fellow candidate.

  Slutsky, born in 1968, is the leader of the ultra-nationalist Liberal Democratic Party and has rich professional experience. Since 1999, he has served in the State Duma and successively served as the first vice-chairman and chairman of the State Duma International Affairs Committee. Because he has a doctorate in economics, he has served as a teacher in colleges and universities, a senior bank manager and an adviser to the mayor of Moscow. It is worth noting that slutsky has been accused of sexual harassment, violation of traffic regulations, bribery and many other charges, among which Nabal also accused him of illegally accumulating wealth. Since 2014, slutsky has been sanctioned by many countries in the United States and the European Union for supporting Putin’s policy on the Ukrainian crisis.

  Harry Tonov, born in 1948, is a member of the Russian Communist Party of party member. He is the oldest of the four candidates. Harry Tonov, a former party member of the Agricultural Party, has served in the State Duma since 1994. He quit the Agricultural Party in 2007 because he was dissatisfied with the cooperation between the Agricultural Party and the United Russia Party, and joined communist party in 2008, with strong support from zyuganov. Since 2011, he has served as the chairman of the Far East and Arctic Development Committee. Harry Tonov once participated in the presidential election on behalf of the Russian Communist Party in 2004, with 13.69% of the votes second only to Putin. Although Harry Tonov opposed Putin’s series of propositions, Harry Tonov was sanctioned by the United States and the West for supporting Putin’s position on the Ukrainian crisis.

Several forces in Russian politics today


  The political map of Russia has changed greatly in the past 24 years. Yekaterina Denzova, a candidate who opposed the Russian-Ukrainian conflict, announced that she would participate in the 2024 presidential election as an independent candidate and launched an anti-war political platform, but the Russian Central Election Commission rejected her nomination. Later, Deng Zuowa found another way to set up the Dawn Party, but it still ended without results. And Deng Zuowa had the same experience as Najreddin, who sharply criticized the "special military action". Although Najreddin won the signature support of more than 100,000 voters, it was questioned.

  In fact, even if Deng Zuowa and Najreddin can participate in the presidential election, they will not pose any threat to Putin. However, the Russian Central Election Commission still prohibits them from participating in the election for the same reason, and there is no information about these two candidates in the final list of candidates.

  Gou Liwu pointed out that after the disintegration of the Soviet Union, all the participating republics started the so-called "democratic transformation" to varying degrees, and also established a political party election system similar to that of the West during this period, but some of them did not completely copy the free election system of the West, but merged their own political traditions. Russia, Ukraine and Belarus have all participated in the presidential election independently. In Russia, Yeltsin, the first president, and then Putin and Medvedev all participated in the presidential election in an independent capacity and were successfully elected president. In Ukraine, the first President kravchuk, and later Kuchma and Yushchenko all participated in the presidential election as independent candidates and were successfully elected. In Belarus, from 1991 to the present, all previous presidential candidates participated in the presidential election as independent.

  It is worth noting that Putin is not the leader of the All-Russian Party, but the leader of the All-Russian People’s Front. As a political party alliance, the All-Russian People’s Front includes United Russia Party, Just Russia-Patriot-For Truth Party, All-Russian Party "Motherland" Party, Newcomer Party, Russian Ecological Party "Green Party" and Russian Progressive Socialist Party. In Russia, in 2018 and this presidential election, although Putin participated in the presidential election as an independent candidate, he also had an identity as the leader of the All-Russian People’s Front.

  According to the Russian election law, non-political party candidates need to be nominated by a group of at least 500 supporters, in addition, at least 300,000 supporters’ signatures need to be collected. The groups that nominated Putin included senior officials of the ruling United Russia Party, famous Russian actors and singers, athletes and other public figures. Therefore, Putin’s participation in the election as an independent candidate shows to a great extent that he represents the interests of all Russian people, rather than representing Russia through a certain political party.

  Apart from the All-Russian People’s Front led by Putin, what are the main forces in Russian politics today?

Above: Russia will hold a presidential election from March 15th to 17th, 2024, and the voting will last for three days.

  Xu Changzhi, deputy secretary-general of the Sino-Russian strategic cooperation high-end cooperation think tank of the China Academy of Social Sciences and a researcher at the Eurasian Institute for Social Development of the the State Council Development Research Center, said that according to the traditional classification method, there are probably several forces in the Russian Federation’s current political arena: first, the United Russia Party represents the traditional center-right forces; The second is the Russian Republic, just Russia-patriots-for the truth party, belonging to the center-left; The third is the liberal democratic party, which represents the extreme right forces; The fourth is the newly established New People’s Party, which is also a center-right force, but it is different from the traditional center-right force represented by all-Russian party representatives. It mainly represents young people who support the center-right position.

  Since he became acting president of Russia on December 31, 1999 and took office on May 7, 2000, Putin has been in power for 24 years, from being president to being prime minister and then being president. In the past 24 years, various forces in Russian politics have probably developed in two ways: one is to be incorporated into the system and become the opposition in the establishment, such as the Russian Communist Party, the Communist Party of Russia, the Liberal Democratic Party and the New Party; On the other hand, if you take a position that does not support Putin, you will either be driven out of the country, put in prison, or fail to register as a presidential candidate.

Navalny’s death has limited impact.


  It is particularly noteworthy that Russia’s main opposition leader Navalny died suddenly in prison recently. He was once regarded as the only person most likely to influence the presidential election. So, will his death affect the next general election?

Above: Ukraine confirmed that Navalny died of thrombosis.

  Navalny, who is of Russian and Ukrainian descent at the same time, graduated from Russian People’s Friendship University, Federal University of Finance and Economics and Yale University successively. In 2000, he joined the United Democratic Party of Russia "Yabolu" and began to go into politics in 2002. Because of the discrepancy between his ideology and his political party, he was expelled from the party in 2007.

  Later, he began to become a Russian dissident leader against Putin, and during the election of the Russian State Duma in 2011, he accused the United Russia Party of cheating in the election, organized demonstrations, and eventually turned into a nationwide anti-Putin incident and was arrested and imprisoned. On December 30, 2014, Navalny was found guilty of fraud and sentenced to imprisonment with a three-and-a-half-year suspension. However, in 2016, the Supreme Court of the Russian Federation overturned this judgment.

  In 2018, he was arrested several times, but was quickly released. In August 2020, he was suspected of being poisoned on his way back to Moscow from Siberia by plane, and Putin approved him to go to Germany for treatment. Navalny said that the behind-the-scenes ambassador of the "poisoning" incident was the Russian government, while the Russian government believed that it was directed and performed by Navalny and western intelligence agencies.

  After escaping a robbery, he returned to Moscow in January 2021 and was detained as soon as he arrived at the airport. In 2021, he was sentenced to three and a half years in prison for economic crimes, and in 2022, he was sentenced to nine years in prison for contempt of court and election fraud. In August last year, he was sentenced to 19 years in prison for sedition and other crimes.

  In December last year, Navalny’s spokesman claimed that after losing contact with him for three weeks, he found that he was transferred to the third prison of Yamal-Nenets Autonomous Region in Siberia to serve his sentence. On February 14th this year, he also sent a message to his wife, You Liya, on social networking sites through his lawyer, with sweet photos of them. Unexpectedly, two days later, he died unexpectedly …

  In response to Navalny’s accidental death, the EU adopted the 13th round of sanctions against Russia, and the United States also imposed a new round of sanctions on Russia. Ironically, later, the Ukrainian side announced that the information from the intelligence system that Navalny died of thrombotic disease indirectly proved that he was not killed by Putin. "According to the official Russian poll data, Putin’s public support rate still maintains an absolute advantage of 75%, so even if Navalny’s accidental death will have a certain impact on Russian society, in the early days of the’ special military operation’, the Russian government has taken countermeasures in the fields of society and public opinion, so it has little impact on the upcoming presidential election." Yan Liwu said. The support rate is as high as 75%, far higher than other candidates who follow closely. This means that in the Russian presidential election in 2024, there is no suspense for Putin to be re-elected. Reporter | Chen Bing

Four highlights of the release of "Tianshu Qitan 4K Commemorative Edition" reveal the secrets of the country

1905 movie network news Produced and directed by Shanghai Animation Film Studio, the classic animation of China officially landed in major cinemas across the country on November 5th, and released a word-of-mouth special. Many viewers who had watched the premiere before spontaneously came to Amway after watching the film, saying that they didn’t know why it was one of the best China animations in the eyes of countless people until they watched the film. "The feeling of watching on the big screen is different", "Let the world know that this is the real China animation" and "Many things with China characteristics that we pursue are in this film".


Since the film was self-edited, the film "Tianshu Qitan 4K Commemorative Edition" has caused many hot discussions among netizens for its sincere display of China traditional culture. At the previous premiere, the deeply rooted role images, funny and humorous story contents and the beautiful national style of brush and ink landscapes were unanimously recommended by many peers in the industry and the media. With today’s release, the film, which was hailed as a "landmark", officially met the national audience on the big screen, and the four behind-the-scenes highlights were also announced one by one.


Aspect 1: Meeting with History Witness the significance of China’s animation inheritance after 38 years.


Thirty-eight years ago, the film was born, and the classics that condensed the efforts of countless artists were born. Fantastic ideas, profound China myths and stories, and extremely advanced role images have captured countless audiences. Today, it is still regarded as one of the best China animations by many people.


Thirty-eight years later, the film "Tianshu Qitan 4K Commemorative Edition" was released nationwide on November 5, spanning the long river of time, and this profound China animation once again entered the public’s field of vision. For the audience who have seen it, this restoration is a gift to let them go back to childhood, while for the audience who have not yet experienced it, this work can make them feel refreshed. Since the development of China animation, the inheritance and innovation behind it have always remained unchanged, and "The Wonder Tan in the Book of Heaven" is one of the important works that cannot be ignored in the development process. Today’s restoration and release is not only popular, but also a lesson from history.


Aspect 2: Talk to yourself and focus on the core of China’s animation "fantastic beauty"


As an animated feature film, the drawing process of "Tian Shu Qi Tan" is full of hardships. According to director Yunda Qian’s recollection, painters judged the time required for the characters’ lines by lip-synching with stopwatches, so as to draw the corresponding mouth shapes of the characters. Painters worked overtime day and night, painting for three years, and finally created this classic in the history of China animation with perseverance and talent. Different from the image of "Gao Daquan" created by mainstream literary and artistic works at that time, "Tian Shu Qi Tan" focuses on the unique aesthetics of strangeness, interest and beauty. The unique character modeling and imaginative strangeness, vivid and three-dimensional interest of various characters and beauty of national art and culture in the film fully show the creative core of China animation.


Famous media people and writers once praised the film’s "family fun" characteristics at its premiere. She sincerely recommended all the audience to take their children into the cinema to watch, and said that the best parent-child relationship is to take their children to watch cartoons they watched as children. The famous film and television director also recalled his childhood fun after watching the film. He once put a cake on his head like an egg. Sometimes the pleasure brought by the film is not only the movie itself, but also the memory and emotion it brings. Well-known film and television actors said that they were very honored to see it in the cinema, and they had no regrets in their childhood.


Aspect 3: Coexistence with the Times, Advanced Interest Adapting to the Choice of Watching Movies for All Ages


The simple but not simple storyline and vivid and interesting character images of "The Wonderful Tale of Heaven" show us the unique features of the Chinese nation, so that folk art, ancient myths and national wisdom can be presented and passed down in the form of animation. Audiences of all ages can find childlike innocence and fun in the film, such as the strange-looking fox mother, which left an indelible impression on many people’s hearts after 70 s and 80 s. For the first-time audience, many plots in the film are attractive enough, such as the cornucopia constantly "copying" dad’s famous scenes, etc. In the previous advance viewing, many people said that "it was the first time I saw it, and it was very novel and fun", which proved that its story content is still out of date and timeless, and it can not only enjoy the visual baptism of the beautiful national scenery, but also appreciate many excellent traditional cultures.


Aspect 4: Blending with the nation and carrying forward China’s excellent traditional culture have a long way to go.


Today, with the prevalence of multiculturalism, many excellent works have emerged in the animation market at home and abroad. The restoration and release of "The Wonder of Heaven" has made many people start to think about the significance of China’s animation. China’s 5,000-year-old civilization has provided a good cornerstone for China’s animation creation. With its unique style and perspective, China Animation School has a special place in the world animation stage, which highlights the fine tradition of China culture and has its own unique national characteristics.


As one of the representative works of China School, the film "The Wonder of Heaven" draws lessons from the artistic elements such as paintings, sculptures, toys and operas in China’s traditional culture, and brings together many folk images, such as a large number of folk music used as background music, and the little emperor marveled at the "birds flying at the phoenix", walking on stilts, dancing dragons and lions and other folk activities, which can be described as a "folk grand view garden". The modeling of the three foxes draws lessons from the traditional Chinese opera facial makeup, which makes the audience unforgettable; The gardens, palaces, courtyards and mountains and rivers in the film follow the "wu school" style, drawing the human landscape with meticulous brushwork and heavy colors, and drawing the natural landscape with elegant ink and wash. The revisiting and attaching importance to the "China School" is, on the one hand, to commemorate the forgetfulness, and, on the other hand, to take history as a mirror to arouse the rethinking of nationalization in China’s animation creation.


The 4K Commemorative Edition of Tian Shu Qi Tan officially landed on the national big screen on November 5, and the classic is full of vitality of the times. I believe it will bring an excellent viewing experience that cannot be missed to many audiences!

Significance of molecular detection in clinical laboratory in accurate diagnosis and treatment of malignant tumor

Author: Zhao Xiaotao 1 Cong Yulong 2

SETTING: 1. Clinical Laboratory of Peking University People’s Hospital, 2. Clinical Laboratory Center of PLA General Hospital.

41121662548624112

Zhao Xiaotao

Deputy Director, Laboratory Department, Peking University People’s Hospital

Chief physician/professor, master tutor. Engaged in clinical molecular detection and related basic research. As the project leader, he was supported by the National Natural Science Foundation of China and the Beijing Natural Science Foundation, and published many core journals and articles in SCI as the first or correspondent author. Major social workers are members (and secretaries) of the Department of Medical Laboratory in peking university health science center; Standing Committee member (and Secretary-General) of Clinical Microbiology and Infection Branch of China Health Care International Exchange Promotion Association; Deputy head of the special working group on scientific research and postgraduate training of Beijing Inspection Society of Chinese Medical Association; Member of Molecular Diagnosis Group of Laboratory Medicine Branch of Chinese Medical Association; Director of Laboratory Specialist Branch of Beijing Medical Doctor Association; Member of the Special Committee of Laboratory Medicine of China Association of Integrated Traditional Chinese and Western Medicine; Standing Committee of Laboratory Medicine Committee of Beijing Society of Integrated Traditional Chinese and Western Medicine; Member of Laboratory Medicine Branch of China Medical Equipment Association; Member of China Medical and Health Care International Exchange Promotion Association, grassroots inspection technology standardization branch, etc.

Malignant tumor is an important disease endangering human life and health, and its incidence has long been at the forefront of disease spectrum and death spectrum, which is a disease of universal concern. The online cloud live broadcast mode was launched for the first time in the 26th National Cancer Prevention Publicity Week held from April 15th to 21st, 2020, and 21.456 million people watched the live broadcast nationwide. This shows that the national medical and health field and the whole society pay attention to the prevention and treatment of malignant tumors. At present, the burden of malignant tumor is still rising in China, which seriously affects people’s health and social life. In recent 10 years, the incidence of malignant tumors in China has increased by about 3.9% every year, and the mortality rate has increased by 2.5% every year. According to the data released by the National Cancer Center in 2019, there were about 3.929 million cases of malignant tumors and 2.338 million deaths in China in 2015. The top five cancers in China are lung cancer, gastric cancer, colorectal cancer, liver cancer and breast cancer, among which lung cancer and breast cancer rank first among men and women in China respectively. At present, the five-year survival rate of cancer patients in China is about 40%, which is 10% higher than that of ten years ago, but there is still a certain gap compared with developed countries. The reason is that early diagnosis, early treatment and precise medical treatment are the key to prevent and cure tumors, and one of its important means is the extensive and effective application of molecular biological diagnosis technology in clinical laboratories.

1. The development of medical molecular biology promotes the wide application of molecular diagnosis technology in precision medicine. 

Medical molecular biology refers to the study of the structure and function of biological macromolecules at the molecular level, so as to clarify the nature of life phenomena. In recent years, with the emergence of new technologies in the field of medical molecular biology and the continuous improvement of bioinformatics data, the level of molecular diagnosis in clinical laboratories has been greatly promoted, and the progress of medical science has been promoted, so that the diagnosis and treatment of diseases in clinical medicine has risen to a brand-new realm, from morphological or cellular level to the explanation of the mechanism and accurate diagnosis and treatment of malignant tumor diseases from gene level and molecular level, so as to achieve early diagnosis and even susceptibility assessment of diseases, and to evaluate the stages, types, treatment effects and prognosis of diseases. Molecular biology has become an important development direction of modern medicine and precision medicine.

In the field of clinical medicine, the application scope of molecular biology technology and methods is expanding day by day, and its research content and technical means are deepening. At present, it has penetrated into all fields of medicine, including molecular detection of pathogenic microorganisms, genetic detection and diagnosis of congenital diseases and hereditary diseases, genetic detection and diagnosis of malignant tumors, as well as individual drug use gene detection that affects drug metabolism, drug resistance and toxic side effects, individual identification, gene detection related to transplant matching, non-invasive prenatal detection (NIPT) and embryo implantation. Among them, gene detection related to targeted therapy of malignant tumor, multi-locus tumor-related gene detection related to heredity, susceptibility, treatment and prognosis, and whole exon gene detection play an important role in accurate diagnosis, prevention and treatment of malignant tumor.

Second, tumor molecular diagnostic markers and new detection technologies provide an important basis for clinical risk assessment of malignant tumors.

In clinical research, it is the direction of clinical medicine, especially clinical tumor research and basic research, to continuously discover new diagnostic markers of malignant tumors and further explore and study the pathological mechanism of malignant tumors. From the discovery of Bence-Jones protein in the urine of patients with multiple myeloma by Henry Bence-Jones in 1846, which was used as the first tumor marker for the diagnosis of multiple myeloma, up to now, more than 100 tumor markers have been discovered, including protein tumor markers, sugar tumor markers and enzyme tumor markers. With the development of molecular biotechnology, there are more and more categories of tumor biomarkers, such as specific gene mutation, which can affect the effect of tumor-targeted drug therapy, genes related to cell growth and differentiation, oncogenes, tumor suppressor genes and their products that play a key role in the occurrence and development of tumors, and single nucleotide polymorphism, genome, transcriptome and proteome can all be used as tumor biomarkers. From tumor-related chromosomal abnormalities to tumor-related genetic abnormalities, from tumor-related single nucleotide polymorphisms to tumor-related epigenetic abnormalities, and the study of new molecular markers such as miRNA and LncRNA provide powerful tools for accurate diagnosis and treatment of malignant tumors in clinic. By detecting these molecular markers, we can assess the risk of cancer and make early diagnosis, monitoring, early warning, intervention,Reduce the risk of cancer and improve the treatment effect, slow down the development of cancer and even prevent the intervention of cancer.

Due to the rapid development of molecular biology technology, the detection of molecular markers of malignant tumors is more and more accurate and efficient. From the discovery of nuclein by F.Miescher in 1868 to the discovery of double helix structure of deoxyribonucleic acid (DNA) by Watson and Crick in 1953, from the invention of polymerase chain reaction (PCR) by Mullis in 1985 to the wide application of NGS NGS((Next-generation sequencing, also known as second-generation sequencing) technology developed in recent years, from the technical means, At present, the Amplified Arrested Mutation System (AMRs) is applied in clinic, which can be used to detect low-frequency mutations and detect 1% mutations in tissues and cells. More sensitive digital PCR technology can detect 0.1% mutation. For the traditional Sanger sequencing, although it is less sensitive, it has advantages in detecting germline mutations, high-frequency mutations, unknown mutations, clear target genes and few genes. NGS technology has the advantage of Qualcomm, which can sequence hundreds of genes, whole exons and whole genomes at one time. With the maturity of technology, more standardized management, continuous improvement and updating of biological information database, and perfection of data interpretation, combined with technologies such as detecting tumor cells in peripheral blood and free nucleic acids in peripheral blood, through overcoming the heterogeneity of malignant tumors,It will greatly promote the development of this technology and have a broader clinical application prospect.

Third, with the diagnosis of cancer patients tailored to provide the best solution for accurate diagnosis and treatment of malignant tumors.

At present, with the continuous development of molecular biology technology and the popularization of molecular diagnosis technology in clinical laboratories, the clinical oncology is increasingly widely used in individualized medicine, precision medicine and targeted therapy. Therefore, the concept of companion diagnostics (CDx) came into being. Adjoint diagnosis is an in vitro diagnostic technique related to special drugs, which can identify the best drug users by detecting the variation of proteins and genes in human body and the expression level of genes. The application of CDx in patients with malignant tumor can not only screen out effective treatment schemes for patients, save the time and cost of ineffective treatment, but also improve the compliance of patients taking drugs and reduce unnecessary toxic and side effects.

The development of accompanying diagnosis shows that the correlation between the expression of estrogen receptor and the efficacy of endocrine therapy in breast cancer patients has been studied since 1970s, from protein level to molecular gene level. Herceptin, the first adjoint diagnostic reagent approved by FDA in September, 1998, was used to detect people who used anticancer drug Herceptin, a humanized monoclonal antibody targeting the extracellular structural region of HER-2 receptor tyrosine kinase. As the driving gene of non-small cell lung cancer, epidermal growth factor receptor (EGFR) has a sensitive mutation rate of 30%~40% in Asian population. TKI (tyrosine kinase inhibitor) is used as a targeted therapy for such non-small cell lung cancer patients, and their survival time is significantly prolonged, and their tolerance and quality of life are higher than those of traditional chemotherapy. Up to now, FDA has approved NGS associated diagnosis and detection products with multiple genes and cancers, covering 324 genes, including microsatellite instability (MSI) and tumor mutation load (TMB). At present, most of the applications of adjoint diagnosis are used in tumors, mainly including clinical management of non-small cell lung cancer, melanoma, breast cancer, colorectal cancer and ovarian cancer. Adjoint diagnosis plays an indispensable role in precision medicine, and its application scope is gradually expanding. It is predicted that it will be developed in the fields of pharmacogenomics, autoimmune diseases, cardiovascular diseases, central nervous system, infection and so on.

Four, clinical laboratory molecular diagnosis quality assurance and technical specifications and market supervision has a long way to go.

The market demand and development potential of cancer medical treatment promote the development and application of In Vitro Diagnosis (IVD) instruments and reagents, and new technologies emerge one after another. On the other hand, institutions for tumor genetic testing have also flourished. The results of tumor detection are related to the diagnosis, treatment and prognosis of the disease, which can be said to be related to the existence of a life. However, due to the high sensitivity and diversity of molecular detection technology, as well as the complexity and uncertainty of specimens and experimental operations, the quality assurance of tumor-related molecular detection is particularly important. From the research and development of reagents and equipment, to the determination of expected clinical use, the establishment and optimization of methods, from the range control of indications to the selection of detection items, methods adopted, the performance confirmation of LDTs or the performance verification of kits, from the selection of specimen types to the collection and transportation of specimens, from the design and layout of space environment to the qualification of personnel, equipment, reagents and technical specifications, from bioinformatics analysis to the interpretation of genetic variation in tumor molecular detection reports, and so on. In order to standardize the medical behavior in the field of tumor genetic testing, the health administrative department has successively issued a number of rules and regulations, and clinical and laboratory experts have also actively formulated national or industry standards, written relevant guidelines, expert consensus, etc., coordinated supervision and liberalization, and jointly promoted the orderly and healthy development of the field of tumor molecular testing.Effectively serve the accurate diagnosis and treatment of clinical malignant tumors. 

With the completion of the human genome project and the post-genome era, as well as the completion of genome-wide association study () of all malignant tumors, more new molecular targets of malignant tumors will be continuously discovered and applied to clinical diagnosis and treatment. At the same time, with the continuous introduction of the application management policy of molecular diagnostic technology and the improvement of supervision, many genetic tests related to malignant tumors will gradually move from basic scientific research to clinical application. The joint application of various molecular biological detection technology platforms, the in-depth study of various new targets, and the intersection and penetration with other disciplines make molecular biological detection play an increasingly important role in the diagnosis, prevention, treatment, drug research and development of malignant tumors. Molecular detection technology in clinical laboratories will help promote the accurate detection, accurate diagnosis, accurate treatment, accurate prediction and accurate prevention of malignant tumors, so that it can serve human health more efficiently and push medical science forward continuously.

Note:This article comes from the topic "Tumor and Adjoint Diagnosis" in the 5th issue of Clinical Laboratory in 2020.

 
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Title map | veer.com  
Original release date | May 8, 2020   

Clinical Laboratory is a journal of medical laboratory technology, with 12 issues a year, each with different topics, tracking industry hotspots, capturing industry direction and paying attention to development frontiers. The electronic version is updated in real time every month, and colleagues are welcome to follow up.

Elva Hsiao’s hot dance in the rain detonated passion. Alan Tam was hugged by male fans

Elva Hsiao


Landy Wen


Chen Chusheng


Kenji Wu


Priscilla Chan

[Click to watch the exclusive video]

 "The Song of the Movie" entered Tongxiang, Jiaxing, and Elva Hsiao featured "Strangers"
 
"The Song of the Movie" entered Wen Lan, Tongxiang, Jiaxing, and the opening ceremony set off a boom. 
 "Movie Song" Walks into the Rain of Wang Feng, Tongxiang, Jiaxing and "Fly Higher"


  Movie network news(Photo/Zhang Hangyuwen/Fifth Tiefeng) On the evening of October 23, the concert "Song of the Movie" was passionately staged in the autumn rain in Tongxiang, Zhejiang. Although the whole concert was held in the rain, the enthusiasm of the audience and the actors on the stage did not diminish at all. The wonderful performances of Chen Chusheng, Wu Kequn, Elva Hsiao and Alan Tam not only made the fans forget the cold rainy night, but also made the atmosphere of the whole concert warm and abnormal. In addition, Wen Lan, An Youqi, Wang Zhengliang, Tong Ange, Li Guyi and Priscilla Chan also won a lot of applause and screams from the audience.

Wu Kequn triggered the first wave of climax, and Chen Chusheng sang deeply and was very popular.

  Wu Kequn’s first song was "your legend", and at this time, when the rain was the heaviest, Wu Kequn sang and danced in the heavy rain, which also triggered the first wave of climax of the audience, and the female fans at the scene screamed again and again. In the second song "Love is Power", Wu Kequn’s affectionate interpretation hit every audience present. Enthusiastic fans rushed to the stage to shake hands with Wu Kequn regardless of the heavy rain and the on-site security guards, and gave their light sticks to idols. "Today’s rain is really heavy, and I see that you are all wet, so the following song is related to wet (poetry)," Writing Poetry for You ",as one of Wu Kequn’s most famous masterpieces, fans sang this song with Wu Kequn while waving light sticks.

  The appearance of another popular singer, Chen Chusheng, triggered the second climax of the audience. "Forgetting in Jianghu" is the theme song of the film being shown. In the drizzle, dancers draw their swords and dance, and an altar of good wine can’t be filled with heroic pride. Chen Chusheng’s affectionate singing shows how many Jianghu children forget in Jianghu. Hawthorn Flower sings another beautiful love story. The last song "Did Someone Tell You" is destined to be a chorus. For Chen Chusheng’s loyal fans, this song touched countless fans on the talent show stage in 2007, and every note represents the best memories of that summer.



Alan Tam


Elva Hsiao Hot Dance Explodes Passion Alan Tam Encounters Male Fan Bear Hug

  As the divas of the whole concert, Elva Hsiao and Alan Tam proved their strength and status with the highest popularity and screams. Elva Hsiao’s dynamic new song "Miss Handsome" with the dance in the rain immediately ignited the enthusiasm of the audience. Elva Hsiao fans sitting in the front row area flocked to the edge of the stage to interact with Elva Hsiao on the stage regardless of the pouring rain. Subsequently, Elva Hsiao’s classic old song "The Most Familiar Stranger" aroused another affectionate chorus in the audience, and both the loyal fans of Elva Hsiao and the general audience sang along with the beat of the music. After Qu Bi, Elva Hsiao said in an interview with the host Hantao Wang that although it was raining heavily, she was moved by the fans in the audience. "I still remember that the first ticketing concert since my debut was held in heavy rain, and a place in Central Taiwan Province was experiencing typhoon weather." Elva Hsiao took another fast song, and "Confession" sang what she wanted to say most to the audience and what she wanted to express her gratitude and gratitude.

  The final climax of the audience came from Alan Tam, who was "25 years old forever". A song "Kara is OK forever" made the older audience stand up and sing in chorus. Alan Tam joked, "I thought everyone had left." The audience at the scene shouted: "Principal, we are here." As an evergreen tree in the music world, Alan Tam’s charm can be said to be unmatched, so that when the second song "Friends" was played, the audience stood up and sang in chorus, which became the climax of the whole concert. An emotional male fan even suddenly climbed onto the stage and gave Alan Tam a "bear hug" from behind, which made Alan Tam dumbfounded. When a song "Love in Late Autumn" was deeply sung by Alan Tam, the whole concert came to the warmest end, and the audience waved their light sticks and sang along gently as they left.


Wang Feng


Wang Feng sang in front of the audience in Yao Di’s hometown in the rain.

  "Life in Full Bloom" made Wang Feng burn the audience’s enthusiasm in the rainy night in the south of the Yangtze River. Then a new song "In Spring", Wang Feng’s dull voice sang the longing for life. "The next song is an old song. I have been singing it for many years, but this time I hope to hear it from your heart." Wang Feng ended his passionate performance with a highly sung "Fly Higher", and the audience completely threw the cold out of the clouds with their hard screams.

  Wuzhen, a water town in the south of the Yangtze River, has attracted countless tourists, and at the same time, it has become the shooting scene of many film and television dramas. There are many scenes in the new version that has just attracted great attention nationwide. Yao Di, the young actor who plays Wang Xifeng in the play, happens to be a native of Tongxiang. This time, in order to meet the folks in his hometown, Yao Di even pushed off a lot of work at hand. "My work schedule was very full these days, but when the concert of" Song of the Movie "found my agent, I said that I must come back to Tongxiang to meet you anyway." A song "Dream of the Red Mansion" won warm applause from the audience.


The four main characters of Song of the Movie, Qu Ning, Liu Lu,Liu YangHe Liu Jiuzhang


The actor of "Song of the Movie" guest sang "Borrowed Starlight" on vcr.

  Although the host of the whole concert was Hantao Wang, the famous host of Michelle’s partner movie channel, there was actually another group of "off-site hosts". They were the four leading actors of the multimedia musical Song of the Movie, Ning, Liu Lu, Liu Yang and Liu Jiuzhang. They shared the simple and elegant natural and cultural scenery of Wuzhen with the audience by recording VCRs, and also introduced the special product "Hangbaiju" of Tongxiang. The four leading actors performed wonderfully in the new musical Song of the Movie, and they just returned from a world tour in Taiwan Province. They sang a song of Song of the Movie, Borrowed Starlight, on the spot, so that the audience who didn’t see the musical Song of the Movie could appreciate the charm of the musical through this short performance.

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