[Editor’s note] In recent years, characteristic towns have sprung up everywhere, which is an important starting point to help supply-side reform and rural revitalization. Regrettably, many characteristic towns have become "performance towns", and it is common to emphasize real estate over industry, development over management, and commerce over culture. How to correct the wrong direction and jump out of the development trap?
　
Today, CCTV Online Review published the second article in a series of comments on "There are many strange images in characteristic towns".

Characteristic towns have become an important "key" for the country to crack the urban-rural duality, industrial agglomeration and cultural inheritance. After the flowers bloom everywhere, problems also follow.In some places, under the banner of "small towns", the practice of "enclosure" has become a replica of real estate development.

　Turning to the list of the top 100 real estate enterprises in China, most real estate enterprises are involved in the development and construction of characteristic towns to varying degrees. Under the general environment of stricter regulation and control of real estate, limited financing and tight finance, housing enterprises "spend the winter" and local governments "tighten their belts" are all facing growth pressure. The characteristic towns seem to be "rain from heaven", and some places and housing enterprises are habitually "agitated".
　
Taking the old road of land finance and real estate development and engaging in "fake towns and real estate" is a "good idea". Some places plan characteristic towns with the idea of building industrial parks under the policy dividend of characteristic towns. Developers use the "hat" of characteristic towns to obtain cheap industrial and commercial land and carry out real estate development; In order to make up for the previous investment, we got a lot of high-quality and cheap secondary land from the local government through the first-level land consolidation for development, and made huge profits through the price difference, which pushed up the local housing prices.
　
We should guard against another bubble bursting. Although the early investment and construction of some characteristic towns are inseparable from real estate development, they even need real estate sales and rental. The terrible thing is that the concept of housing enterprises has not changed, and towns have been developed by the way of making money in the past, with emphasis on marketing and light operation, and with stories and concepts, local housing prices have been inflated, which has discouraged enterprises and talents from making money and leaving them, leaving "empty towns" and "ghost towns".
　
The development and management of characteristic towns is a delicate work, but also a slow work, which should be treated with the spirit of "embroidery needle"If you can’t make it, it’s a political achievement. If you screw it up, it’s an experiment. We should scientifically certify and strictly examine and approve characteristic town projects, especially those involving the linkage of primary and secondary land markets and a large number of one-off land purchases, so as to prevent some bad real estate developers from deviating from the original intention of the country to build characteristic towns, exploiting policy loopholes and engaging in real estate in disguise.
　
The development level of characteristic towns in China is still small and new, so it is inevitable to go through the process from "chaos" to "governance" and be prepared for "long-term success".Previously, the regulatory authorities delineated four red lines in the construction of small towns: "strictly guard against government debt risks, strictly control the tendency of real estate, strictly save intensive land, and strictly observe the red line of ecological protection", and also delisted a number of unqualified towns. A town with real vitality is an endogenous cycle of industry, with a unique culture, and the people live and work in peace and contentment. It is by no means a high-rise building or an image project. The process of cultivating characteristic towns must be long-term, which is the result of market choice. If administrative means are not ordered, money cannot be spent.
　
The development of characteristic towns should be guided by the trend, adapted to local conditions, suitable for local customs and humanities, and stand the test of history. In practice, we need to be targeted, focus on the existing industrial base and regional future planning according to the economic characteristics of various places, and selectively carry out pilot projects for the construction of characteristic towns. We should not rush into the horse and start work quickly. We need to make a decision before making a decision, tailor our measures, explore successful experiences through meticulous cultivation, and then gradually spread them out, so that the construction of characteristic towns can truly become an important carrier for high-quality economic development and cultural inheritance.

　　In the first quarter, Guangdong invested 0.31 trillion yuan in real estate development, down 2.7% year-on-year. Among them, investment in commercial housing decreased by 1.2%.

　　Regionally, the investment in real estate development in the core area of the Pearl River Delta decreased by 1.9%, the coastal economic zone decreased by 3.1%, and the northern ecological development zone decreased by 11.1%.

　　annotations

　　1. Interpretation of main indicators

　　Investment completed by real estate development enterprises this year: refers to all the investment completed during the reporting period for housing construction projects, land development projects, public welfare buildings and land purchase fees. This indicator is cumulative data.

　　2. Statistical scope

　　All real estate development and operation legal entities.

　　3. Investigation methods

　　Conduct a comprehensive survey on a monthly basis (except January).

　　4. Division of economic regions

　　The core areas of the Pearl River Delta include 9 prefecture-level cities including Guangzhou, Shenzhen, Zhuhai, Foshan, Huizhou, Dongguan, Zhongshan, Jiangmen and Zhaoqing. The coastal economic belt (east wing and west wing) includes seven prefecture-level cities: Shantou, Shanwei, Chaozhou, Jieyang, Yangjiang, Zhanjiang and Maoming. The northern ecological development zone includes five prefecture-level cities: Shaoguan, Heyuan, Meizhou, Qingyuan and Yunfu.

　　5. Calculation of growth rate

　　In this paper, the year-on-year growth rate of real estate development investment is nominal growth rate.

Xintai Line, which is under the jurisdiction of Jinan Railway Depot, Jinan Railway Bureau, has many crossings, pedestrians and vehicles. The attendant in the driving room promptly informs the crossing workers that there is a train passing by, so as to prevent the problem of "mistakes, omissions and forgetfulness", which is very important for crossing safety. Since the development and application of crossing warning system in this section, whenever a train approaches the station, the system will send out a voice warning to remind the duty officer to inform the crossing workers, and the crossing safety has realized double insurance of machine control and human control.

The person who developed this crossing prompt system is Lu Baohua, the director of the technical department of Jinan Railway Depot. Over the years, Lu Baohua has researched and developed more than 40 safety management application systems. At the end of last year, he became an outstanding professional in the first batch of "1231" backbone talents project of Jinan Railway Bureau, and enjoyed the talent allowance.

From "soil expert" to "programming expert"

It’s true that Lu Baohua is a "soil expert". He graduated from high school, has no training in programming professional systems, and has been studying hard just because he likes to study electrical maintenance and computer technology, and has become a "master" who can write programs and software. 　　

In 1986, Lu Baohua worked as a connector at Zaoyuan Station for two years, and then transferred to Duan to be responsible for the maintenance of shunting walkie-talkies, which lasted for more than 30 years.

During his work, Lu Baohua became interested in computers. At that time, the price of a desktop computer was 30 thousand to 40 thousand yuan, while the monthly income of employees was only 100 yuan. In order to study computer principles and learn programming techniques, Lu Baohua saved 2000 yuan, bought motherboards and accessories, and assembled an 8086 computer with a shoe box as the chassis and a black-and-white TV as the screen. It is this machine that runs DOS system, has no mouse and hard disk, and has opened another field that he still loves today — — Computer programming.

The road to study and study technology is boring, but the experience of exploring new knowledge is happy. In order to understand the programming language, he dug out the high school textbook again and carefully reviewed English words; In order to understand the concept of function, he humbly asked young students; In order to adapt to the hardware upgrade, he scrimped and saved to update accessories.

Heaven rewards diligence. After several years of self-study, Lu Baohua mastered the programming technology. In 2000, he completed the compilation of the home page of the first office network in the train operation depot. Today, the homepage of Duan Office Network, which has been revised by him for many times, has maintained stable and efficient operation.

Concentrate on programming and take the lead

In 2004, Lu Baohua undertook the important task of developing the "Safety Management Information System" in the section. Compared with office web pages, this system is more logical and complicated to write.

Combining his years of driving experience, he began a difficult climb in the field of programming. He learned and tried again and again, analyzing function by function, testing module by module, writing down millions of bytes of code, and often reinventing himself because of a new inspiration and a new idea.

After half a year’s unremitting efforts, the "Safety Management Information System" has been developed and successfully put into use. Section safety management, information reporting and problem handling have been networked, open and visualized, and safety management has become more standardized and efficient. In 2005, "Safety Management Information System" won the third prize of scientific and technological progress of Jinan Railway Bureau.

Since then, Lu Baohua has provoked the whole system development, and successfully completed one management system after another. His newly developed version of "Safety Management Assessment System" has realized the intelligent management of safety problem entry, inquiry, statistics and assessment, greatly improved the work efficiency and made the assessment more open and transparent. The "Construction Management System" developed by him manages all the information such as construction content, registered stations, related stations, speed limit, safety measures, marking and controlling personnel, etc., and the formulation, review and approval of construction safety measures and operation processes are all carried out online, and the safety agreements signed with various units are also entered into the system, which makes the responsibilities and rights of construction safety management more clear and the process records well documented.

Strive for Excellence and pursue the ultimate

Lu Baohua is a persevering person who strives for perfection, and constantly revises and perfects the developed system to achieve perfection. The "Electronic Account Management System" developed by him was officially put into use in January this year. Information such as which reports each station needs to report, whether there is any omission or late reporting, whether the account records are filled in in time, etc. can be seen at a glance on the Internet, and the account is paperless.

Although the system has won unanimous praise from cadres and workers after its application, Lu Baohua feels that there is still room for improvement. He pointed to the computer screen and said, "When you look at this spreadsheet, when you pull it down, you can only see the numbers line by line, but you can’t see the column contents above, which is very inconvenient, so I made an improvement to make the column contents move down automatically with the table, so that even if you look at the numbers in the bottom line, you can know which column contents it is." Lu Baohua said this problem, many people will encounter at work, but he used his "super brain" to solve this problem for everyone.

Lu Baohua, 53 years old, has an ingenuity of Excellence and perfection under his ordinary appearance. He said: "every management system developed is a work made with painstaking efforts. Striving for perfection is my pursuit of work and the joy of my life." (Text/Jing Hui Wang Tian)

Recently, the topic of "the face value of Nortel School Flowers after 00" has set off a hot discussion in Weibo. Rao Jiadi, the flower of Nortel School after 00, entered the hot list with outstanding face value and unique temperament. Rao Jiadi, a new school flower, not only conquered many netizens with her beauty, but as a new actor, she has tried different styles of roles in many excellent works with her solid basic skills and deep understanding of roles. These works to be broadcast continue to attract the attention and expectation of netizens with her excellent production team and excellent cast!

In the "Fox Demon Little Matchmaker Wang Quan" co-starred with Cheng Yi and Li Yitong, he played the beautiful snow demon with a black belly; Esther Yu and Ding Yuxi co-starred in "Staring at the Milky Way at Night", playing a witty and kind peach. The latest work is "Jin Yue Ru Ge" starring Zhou Ye and Cheng Lei, and it is also a work that has attracted much attention from netizens recently. The work being filmed is "How to Beat Her Charming" co-starred with Jelly Lin and Alen, in which she plays the innocent and innocent Liu Tang. Rao Jiadi constantly deepened his understanding of performance in his role changes again and again.

As the school flower of Nortel, Rao Jiadi is naturally widely recognized in terms of face value. Her innocence and charm coexist, whether it’s a sweet smile or a loving eye, people will never forget it. And her modeling in the play is even more varied. This kind of immortal face value with exquisite makeup adds a lot of highlights to her dramatic increase in waiting to be broadcast.

Rao Jiadi’s drama to be broadcast covers a variety of types of people, from gentle and lovely to enchanting and black, and each work is full of challenges and surprises.

Xiaobian also found that this school flower is not only as simple as the face value. Privately, Rao Jiadi is a treasure girl with many possibilities. Surprisingly, Rao Jiadi also participated in the short film of the opening ceremony of the 2022 Winter Olympics-Countdown: beginning of spring.

At that moment, she interpreted her youth and dreams in a different way. Her figure shines on the screen, showing the vitality and grace of China youth to the world. This experience has undoubtedly added a lot of color to her multifaceted life.

In private, Rao Jiadi is a ghost horse girl full of youthful vitality, sometimes quiet, sometimes jumping out, having her own unique spiritual world, full of curiosity and keeping love for the world. The photo of the private server makes Xiaobian feel that Rao Jiadi has a natural feeling of coolness and no distance. There is always something special about beauty, and Rao Jiadi’s canthus mole also increases her recognition among the flowers.

In the future, with the series of dramas to be broadcast, I believe Rao Jiadi will give back the love of netizens with more vivid characters and excellent works. Let’s look forward to the wonderful blooming of the 00-year-old Nortel school flower on the screen, which will bring us more surprises and touches! # Rao Jiadi’s new drama expectation # # Nortel school flower Rao Jiadi # # Yan value and strength coexist #

On November 10th, China Fudan Hospital Ranking was just released, which was released by Hospital Management Institute of Fudan University. Drawing lessons from the evaluation method of "Best Hospital Ranking" in the United States, it adhered to the core of clinical discipline level and specialty reputation, taking into account the scientific research output of that year, which attracted great attention.

However, on a global scale, which city has the strongest comprehensive strength in cancer treatment, do you know? A few days ago, Britain also published a "list of the best hospital cities in 2019", which evaluated the overall level of cancer treatment in 100 cities around the world from three aspects: infrastructure, nursing quality and access rights.

The survey found that Tokyo, Japan is one of the best cities for cancer treatment in the world. Japan’s capital ranks first in the efficiency of cancer treatment, with the highest score in the overall quality of diagnosis and treatment, the largest number of first-class hospitals, and a high score in accessibility.

The second best hospital for cancer treatment in the world is located in Boston, Massachusetts, USA. Its infrastructure score is the highest, including the number of first-class medical universities, first-class hospitals and sufficient mental health counseling experts for patients.

The third place is London, England, followed by Paris, France, and Seoul, South Korea ranks fifth. It should be emphasized that this survey only examines the overall situation of hospitals in specific locations, not individual institutions.

Beijing is the only city in China, ranking 83rd. It performed well in the management of adverse events, drug prices and disposable medical expenses. In contrast, Beijing, Dubai, United Arab Emirates and Krakow, Poland were rated as the three cities with the worst cancer treatment efficiency, indicating that we still have a lot of room for improvement.

01

Japan, the leading cancer treatment technology in the world.

As early as 30 years ago, Japan began to study cancer cure methods and constantly broke through innovation. Among them, the professional anti-cancer physical examination institution, the specialized cancer treatment hospital, has long been famous all over the world.

Nowadays, Japan has gradually formed a mature cancer screening, cancer treatment and cancer recurrence prevention as three steps to prevent and treat cancer. No matter TV, magazines and new media, they will try their best to popularize the significance of early onset and active treatment of cancer, which has been endorsed by many medical schools and research institutions at home and abroad.

Japan’s 30 years of painstaking research on cancer has created a world-leading cancer prevention and control system, making Japan second to none in the field of cancer treatment in the world, thus attracting a large number of foreign patients to receive treatment and examination.

Japanese cancer treatment has three characteristics: high cure rate, small side effects and low recurrence rate. Before receiving Japanese cancer treatment, the patient underwent a Japanese cancer physical examination, and the smallest cancer below 5 mm can be found, which is in stage I, and the cancer cells have not infiltrated (on the epidermis and mucosa, and have not penetrated into the muscles), spread (spread to all organs), metastasized (transferred to other organs), or even stage 0 (primary cancer). It is fortunate to find such a cancer, which can be cured by resection. If you pay attention to lifestyle changes, it will generally not recur.

Known as the king of cancer, the early detection rate of pancreatic cancer is very low, only 5% ~ 7%. If doctors are inexperienced, pancreatic cancer is often misdiagnosed as gastrointestinal or hepatobiliary diseases, and the misdiagnosis time is generally as long as 3 ~6 months. Most patients can’t be surgically removed when they are diagnosed, and they will die in about half a year, and the survival rate after 5 years of operation is less than 5%.

In Japan, the 5-year survival rate of pancreatic cancer can be kept at a high level of about 42% through early cancer prevention and early treatment.

Good treatment, we must protect the normal tissue.

Japan’s leading cancer treatment technologies mainly include heavy ion therapy and proton therapy. Among them, heavy ion radiotherapy and proton radiotherapy are the most advanced radiotherapy methods to treat tumors, and their clinical effects are comparable to those of scalpels.

Doctors only need to aim the particle beam of heavy ions and protons at the tumor to take a photo, and the tumor tissue will die quickly. It has almost no harm to the healthy tissue around the tumor, and it sweeps away the skin damage, visceral damage such as radiation-induced pneumonia, bone marrow suppression, hair loss, low immunity, etc. brought by all the common radiotherapy methods at present, and it has no bleeding, infection, accidental injury, etc. caused by the scalpel, so it is called the magical invisible scalpel.

02

Heavy ion therapy

Heavy ion therapy is mainly used to treat local malignant tumors, especially diseases that are difficult to cure by traditional methods. Compared with other common radiotherapy, it can accurately locate tumor tissue and reduce the damage to surrounding normal tissue.

Because the types and spread of cancer cells are different, the treatment methods are also different. Whether heavy ion therapy can be carried out needs to be judged in advance. According to the comprehensive research institute of radiation medicine, the statistical results of patients who have received heavy ion therapy so far clearly show that:

(1) It has a good effect on treating the following malignant tumors, namely, cervical cancer (including eye cancer), intracranial and skull base cancer, lung cancer, liver cancer, prostate cancer, bone cancer, soft tissue cancer, uterine cancer and local recurrence in pelvis after rectal cancer operation.

(2) A series of cancers that are resistant to ordinary radiation (such as X-rays) have a good effect, such as well-differentiated adenocarcinoma, adenoid cystic carcinoma, hepatocellular carcinoma, bone cancer, cartilaginous carcinoma and malignant melanoma.

However, large-area metastatic cancer is not suitable for heavy ion beam therapy. There are patients such as hematologic cancer, gastric cancer, colorectal cancer (primary site), and patients who have received radiotherapy in the same place before. Please consult a doctor for details.

03

Proton therapy

Proton particles are extremely tiny, and one trillion protons are only one millimeter long in a straight line. Protons are positively charged, which can be made to move at high speed by electric field, reaching extremely high energy. Using proton accelerator to generate high-energy proton beam, which is injected into human body under precise control, can accurately release energy to the lesion to achieve therapeutic effect, which is the technical superiority of proton therapy.

Because proton therapy has the characteristics of strong penetration, good dose distribution, high local dose, less side scattering and small penumbra, it is especially suitable for treating tumors surrounded by important tissues and organs.

The cancers suitable for proton radiation therapy mainly include head and neck cancer (nasal cavity and paranasal sinuses, throat, salivary glands, skull base, etc.), lung cancer, liver cancer, prostate cancer, bladder cancer and other primary tumors. In addition, it can also treat pelvic recurrence and single metastatic tumors (liver metastasis and lung metastasis) after rectal cancer surgery.

We live in an era when we talk about the discoloration of cancer. Cancer is not an incurable disease, but a chronic disease that can be prevented in advance, that is to say, cancer is not a terminal disease.

For patients, if cancer is unfortunately detected, we must pay attention to the opportunity of "first treatment". Because the medical results are often irreversible, the chances of cure for almost all cancers may mainly depend on the first treatment. Japan is a country that attaches great importance to surgery, and the top hospitals for cancer treatment are all famous for surgery. For patients who have surgery opportunities, they can make rational choices according to their own conditions.

According to the Nihon Keizai Shimbun, 75% of cancer patients in Japan did not leave their jobs due to illness, and 80% of them said that their treatment would not affect their work. The reason is that most cancer patients in Japan are found early and treated early, and early cancer can be basically cured without affecting their normal work and life.

04

Cancer screening

Toshiba Corporation of Japan issued a statement on November 25th, saying that it has developed a method to diagnose cancer through blood test with an accuracy rate of 99%.

The basis of diagnosis is to determine the type and concentration of small noncoding RNA molecules secreted by cancer cells into the blood. The whole analysis process only needs one drop of blood and lasts about two hours. Therefore, the company has specially developed a portable device with a built-in diagnostic chip.

This method can diagnose 13 kinds of cancers, including gastric cancer, breast cancer, liver cancer, esophageal cancer, pancreatic cancer, intestinal cancer and bladder cancer. Toshiba said that even in the earliest stage of cancer, this method is still effective.

In recent years, the number of cancer patients has been increasing, and Japan has been actively developing new anti-cancer methods. Moreover, in this respect, artificial intelligence has begun to be more and more widely used.

In addition, according to statistical reports at home and abroad, the comprehensive cure rate of gastric cancer in Japan is as high as 80%, and the first-stage gastric cancer even reaches 98.1%! Far more than 30%~40% in China and the United States, it can be said that it stands out from the crowd and dumped us several blocks. Rich people can go to Japan for physical examination and surgery. What should ordinary people do?

We might as well learn from Japan’s anti-cancer experience, and truly achieve early prevention, early detection, early diagnosis and early treatment, and reject gastric cancer thousands of miles away!

The 5-year survival rate of gastric cancer in Japan is high, because most of the patients detected are early patients, the disease develops slowly, and the probability of recurrence and metastasis is low. At the same time, because of their young age and good physical condition, they are more tolerant to surgery, radiotherapy and chemotherapy, and the treatment effect is of course good. Japan’s secret to deal with gastric cancer is early screening, early detection and early treatment.

In 1964, 400,000 people were screened, by 1970, 4 million people were screened, and after 1990, about 6 million people were screened for gastric cancer every year. The early diagnosis rate of gastric cancer in Japan is as high as 50% to 70%, while the cure rate of early gastric cancer is more than 90%, even close to 100%.

In the United States, the incidence of gastric cancer is very low, which is a rare disease. Compared with breast cancer, colorectal cancer and prostate cancer, Americans pay relatively little attention to the prevention and treatment of gastric cancer, and the early detection rate is low. China is a country with high incidence of gastric cancer, but people’s awareness of prevention and treatment is not high. Only 10% to 15% of early gastric cancer is found, and many people are diagnosed with advanced gastric cancer. More than 70-80% people will not live for five years. Many people died within a few months after being diagnosed.

Since the cure rate of gastric cancer in Japan is so high, it is attributed to the early detection and treatment of gastric cancer in Japan, so how do they do it? Very simple, mainly relying on endoscopic screening. In the eyes of many people in our country, gastroscopy is a color-changing examination. Many people delay their illness because they refuse gastroscopy, and few people take the initiative to ask for gastroscopy unless they have to.

According to reports, Japan has a population of about 127 million, and about 15 million cases of gastroscopy are completed every year. It is equivalent to 12.5% of people having a gastroscope every year. Converted, it is equivalent to that 62.5% people have had a gastroscope at least once in five years. Convert it into high-risk groups, and almost all of them have been screened.

On the other hand, in China, many people are afraid of gastroscopy. The detection rate of gastroscopy is very low, the detection rate of early cancer is less than 20%, and the survival rate in five years is less than 30%. That is to say, most people who are diagnosed may not survive for five years. 80% of patients with early gastric cancer have no obvious symptoms, and even if there are symptoms, they are atypical symptoms, such as loss of appetite and abdominal discomfort, which are difficult for patients to pay attention to. Only regular gastroscopy can find its clues.

According to the latest 5-year survival rate data of gastric cancer released by National Cancer Research Center of Japan:

The 5-year survival rate of primary gastric cancer is as high as 98.1%.

Secondary gastric cancer: 66.4%,

Stage III gastric cancer: 47.3%,

The 5-year survival rate of stage IV gastric cancer is only 7.3%.

Because the proportion of advanced gastric cancer in Japan is very small, the overall 5-year survival rate is higher than 80%, which is unique in the world! It can be seen how important it is to find and treat early! Compare the figures in China: the overall 5-year survival rate is less than 40%; Stage 3 or 4 gastric cancer accounts for 80% of the total cases, and the 5-year survival rate is less than 30%. Only 15-20% of patients have early cancer. In other words, most patients will not live for five years.

Because of its large population base and high incidence of gastric cancer, China has contributed more than half of the cases in the world. Under the background that there is no revolutionary progress in the treatment of gastric cancer at present, it is particularly important to do a good job in the prevention and early screening of gastric cancer.

On the evening of March 30th, GAC Chuanqi’s brand-new medium and large SUVS7 was officially launched. Six new models were launched, with a guide price range of 175,800-229,800 yuan and a limited-time price of 169,800-223,800 yuan. After adding the national replacement subsidy, the price further dropped to 154,800-208,800 yuan.

As the brand’s first production car equipped with a high-level intelligent driving system, the new car is built on the new energy platform of Guangzhou Automobile EV+, and it cuts into the market with the dual core of plug-in and intelligent driving, facing the needs of home users for long battery life, intelligence and high cost performance.

Chuanqi yearns for S7 to adopt the design language of "hiding the front and embellishing it", with a closed front face with a 2618mm penetrating light strip and a split headlight group, and a built-in 2248 beads, which supports the upgrade of OTA light language and the interaction with breathing light, and the recognition is full at night. On the side of the car body, the suspended roof, hidden door handle and 20-inch spoke wheel hub enhance the sense of technology, and the tail is similar to a zigzag through the light group and the dynamic light effect echoes the front face design, giving consideration to the sense of strength and futurity. The new car offers five basic color schemes and two-piece/matte options to meet individual needs.

The interior of the new car takes the 270 embracing cockpit as the core, and is equipped with Qualcomm Snapdragon 8295P chip and ADiGO 6.0 system, which supports four-tone voice interaction and 27-inch W-HUD head-up display, realizing "visible and controllable". For family travel scenes, the rear row is equipped with a 17.3-inch 3K ceiling screen, a 22-speaker Dolby panoramic sound response and a 20L cold and warm refrigerator, giving consideration to entertainment and practicality. In terms of intelligent driving, the new car is equipped with NVIDIA Orin-X chip (254TOPS computing power) and 11 cameras+laser radar combination. The self-developed end-to-end system of GAC covers 357 sub-scenarios, such as urban/high-speed NDA and extreme parking spaces, and the intelligent driving function in urban areas is free for life, which significantly reduces the threshold for users to adopt advanced intelligent driving.

In terms of power, the new car offers the choice of plug-in and extended-range power. The plug-in version is equipped with a plug-in system consisting of a 1.5T engine, and provides a single-motor version and a dual-motor version. Among them, the maximum power of the 1.5T engine is 118kW, the single-motor version is equipped with a 170kW front drive motor, and the four-wheel drive version is equipped with a 170kW/80kW front and rear dual motors. CLTC has a pure battery life of 180-205km and a comprehensive battery life of 1020-1150km. The whole system supports 17-minute fast charge (30%-80%) and 6kW external discharge, taking into account the long-distance endurance anxiety relief and outdoor power demand.

From the perspective of positioning and pricing, we look forward to popular models such as S7 sword finger and so on. Compared with the ideal L6, its limited-time starting price is as low as 154,800 yuan (after subsidy), and it offers lidar version and four-wheel drive options, so its intelligent driving function and endurance performance are more competitive. At the same price, Chery Fengyun T10 and other models are also difficult to fully compete with them in the intelligent cockpit and intelligent driving configuration.

Conclusion:

In 2025, the competition in the large and medium-sized new energy SUV market is fierce, and Chuanqi yearns for S7 to cut in with the strategy of "high entry price", filling the gap of the brand in the 200,000-class smart SUV market. Combined with leapfrog configuration, full-scene intelligent driving and technical accumulation of GAC Chuanqi in the hybrid field, the new car is expected to become a new choice for home users. If the terminal channel and service experience are improved simultaneously, it will become the key engine to drive the sales growth of Chuanqi.

One really dares to accuse, and the other really dares to send it.

Because of a manuscript on 26th, we received a lawyer’s letter from Shanghai Branch of Junhe Law Firm entrusted by Pong Pong (China) Co., Ltd.

According to the lawyer’s letter, on October 26th, 2022, the "New Economy IPO" published an article entitled "Hidden Corner under the Epidemic Situation: Low-key IPO of Shanghai Epidemic Protection and Supply Unit, with a gross profit margin as high as 70%". According to the lawyer’s letter, Pong-Pong/Junhe Law Firm believes that when analyzing the financial data of the prospectus, the article indicates that the high gross profit margin of Pong-Pong in the education field is not normal, and implies that Pong-Pong is not normal. These contents have not been investigated, which are seriously inconsistent with the facts and derogatory.

Bang bang/Junhe Law Firm believes that,The article has brought a great negative impact on the commercial reputation and market image of pong, and caused great losses, which seriously violated the reputation right of pong.

Then, Pang Pang Xiang/Jun He Law Firm put forward three requirements:

1. We issued an apology statement in WeChat official account within 2 working days after receiving the lawyer’s letter, asking us to explain that the content of the previously published article on the gross profit margin of pong ring was not investigated and did not conform to the facts; In addition, I asked for an apology to pong.

2. Stop spreading or publishing "false, inaccurate" information about pong.

3. If the above two items are not implemented, the civil and criminal responsibilities of the "new economy IPO" will be investigated.

Frankly speaking, it’s not the first time I’ve received a lawyer’s letter from a new economy IPO, but it’s the first time I’ve seen such impudence as banging. One really dares to accuse, and the other really dares to issue it! We are almost scared to draft an apology letter. However, before writing an apology letter, we would like to discuss a few questions with Pang Pang Xiang/Jun He Law Firm:

1) The lawyer’s letter said that our abnormal evaluation of the gross profit margin of Pong Pong Ring was not investigated, which constituted insult and slander, but neither Pong Ring nor Junhe Law Firm provided the real reason for the gross profit margin as high as 40%. The phrase "strong bargaining power" was mentioned in the prospectus, and the lawyer’s letter did not mention it at all. Why did Pong Ring get a gross profit margin far exceeding that of a large number of catering supply chain giants at home and abroad?

There are only overbearing accusations, but there is no solid evidence. In our view, this is tantamount to hooliganism, just like the phrase "strong bargaining power";According to this touching logic, can Somali robbers also say that highway robbery is a kind of "strong bargaining power"?

2) Junhe Law Firm misunderstood our point of view. Our article does mention the following words,

"Commercial bargaining power is usually reflected in the core competitiveness of products, that is, exclusive products with unique formulas or technical content, which often gives suppliers the pricing power to the demand side; Another situation is brand premium, that is, the price floating effect brought by the brand’s own aura, but this generally exists in higher-priced consumer goods or luxury goods.

In kindergartens and school canteens, the core requirements for suppliers’ ingredients are safety and health. There is no exclusive product or core formula for basic ingredients, and there is little brand premium. Compared with other companies, there is no competitive advantage in the supply of basic catering ingredients provided by pong, so it is impossible to form exclusive barriers. Then there are only two possibilities to obtain such a high gross profit margin: one is to exclude competition by other means and realize the de facto regional monopoly; The second is to sacrifice food safety and food quality in exchange. "

According to Junhe Law Firm, we are "suggesting that the banging has eliminated competition by other means, realized de facto regional monopoly, or sacrificed food safety or food quality in exchange for higher gross profit margin".

Actually, it’s not. We only make an appropriate logical reasoning based on the general knowledge in the real business field and the real information disclosed in the prospectus. This logic is suitable for all enterprises in the catering and even retail fields, which is also the basic law that normal business activities should follow. We are opposed to sitting in the right place, and we don’t think there is a surreal existence beyond gravity.

In our opinion, Pong Pong and Junhe Law Firm should take back this lawyer’s letter and promise not to send us similar unfounded allegations. Of course, if Bang Bang can produce strong evidence that its core competitiveness has won it a high gross profit margin of 40%, then we will be happy to apologize publicly.

We are willing to wait for this moment.

This article first appeared on WeChat WeChat official account: New Economy IPO. The content of the article belongs to the author’s personal opinion and does not represent Hexun.com’s position. Investors should operate accordingly, at their own risk.

　　Cctv news: On July 8th, CCTV’s "International Sharp Review" broadcast a commentary entitled "The United States will lose five major potential benefits in launching a trade war", which was reprinted by many overseas media.

　　July 8-9, French LCF Radio Facebook account, Spanish Radio International website, Spanish Huaxia Voice Broadcasting WeChat subscription number, Italian Milan FM89.8 Radio website, Portuguese Iberian Media Group APP, Portuguese Lisbon Rainbow FM website, Brazil Rio Headline China Radio Website, Brazil Sao Paulo World China Radio Website, Turkish Economic Observer Network, Kazakhstan’s "Business News" official website, Jordan Global Radio Facebook account, Facebook account of FM102.9 radio station in Dakar, Senegal, Chinese PT portal, Chinese headline APP, Portuguese new newspaper APP (Facebook account, Twitter account), American International Daily, Nordic Times, Australian ACMEDIA, European Union Chinese website, West Africa online website, Japanese Chinese business network and many other overseas media have reprinted it. On July 9, Hong Kong Ta Kung Pao and Wen Wei Po also published this comment. The main reports are as follows:

　　China Central Radio and Television General Station published a commentary entitled "The United States will lose five major potential benefits when launching a trade war". The article pointed out that since March this year, the trade conflict between China and the United States has been ups and downs, and the Sino-US "trade war" has been shrouded, which has brought many uncertain risks to Sino-US relations and even the world economy. Once the trade war breaks out, both China and the United States will lose both sides, and they will lose huge benefits from five aspects. To think about the problem in a different way, if the two sides can turn hostilities into friendship, they may be able to create a "miracle" in the history of world trade through their joint efforts.

　　The article said that the United States will lose five major potential benefits by launching a trade war. First, it will deprive China and the United States of broad space for future cooperation. If the two countries continue to struggle with the traditional trade deficit and refuse to look forward and far, the prospect of promoting closer cooperation and integration between China and the United States will not exist. Second, it will make China and the United States lose the great benefits brought by the division of labor in the global industrial chain. Third, it will make the world lose the great historical opportunity of economic recovery and warming. According to the research of relevant institutions, if the trade conflict between China and the United States cannot be solved well, its impact will spread all over the world, and world trade will even drop by 40%. Fourth, it will make the international order and international rules formed over the years lose authority and binding, which will lead to chaos in the world economy. Fifth, the most important thing is that the United States will lose China’s huge market dividend. China’s market is developing rapidly. In 2017, the size of China’s market is equal to that of the United States, and China will soon become the largest market in the world. In the next five years, China’s import volume will increase by 10 trillion US dollars. The Sino-US trade war will make the United States lose China’s huge market dividend.

　　The article points out that if the United States can change its thinking, China and the United States can create a new "miracle" from five aspects. First, relax American exports of high-tech products. This alone can increase China’s imports by $100 billion. Second, jointly promote the digital economy. Third, we should accelerate the BIT negotiations. Fourth, strengthen cooperation in the Belt and Road Initiative. Fifth, promote the FTA between China and the United States. According to the research conclusion of Peterson Institute, the two sides can increase the trade volume by 500 billion US dollars.

　　　French LCF Radio Facebook account website forwarded on July 8, 2018

　 　　Spanish Radio International website forwarded on July 8, 2018

　 　　The website of FM89.8 radio station in Milan, Italy was forwarded on July 8, 2018.

　 　　Portuguese Iberian Media Group APP forwarded on July 8, 2018

　 　　Portugal Lisbon Rainbow FM website forwarded on July 8, 2018

　　　Forward on July 9, 2018 on the website of Brazil’s Rio headlines.

　　　The website of the World Broadcasting Station in Sao Paulo, Brazil was forwarded on July 8, 2018.

　　　Turkish Economic Observer Network forwarded on July 8, 2018

　　　Kazakhstan’s "Industry News" was forwarded by official website on July 8, 2018

　　　Jordan Global Radio Facebook account forwarded on July 8, 2018

　　　Facebook account of FM102.9 radio station in Dakar, Senegal was forwarded on July 8, 2018.

　　　Hong Kong Ta Kung Pao was published on July 9, 2018.

　　Hong Kong Wen Wei Po was published on July 9, 2018.

Nowadays, how crowded the track of 200,000-300,000 pure electric cars is, I believe that we can get a glimpse from the fact that the sales scenery is no longer, and new cars like Krypton 007, Krypton 007 and Krypton 007 are springing up like mushrooms after rain. However, the bigger the waves, the more expensive the fish are, and the market is full of flowers. There are always new cars with labels to break down the market and attack the city and plunder the land. The+just officially released is a good example.

At the press conference of the first show, He Xiaopeng said that Tucki P7+ had thought of naming it "Tucki P8", and "+means home, Tucki P7+ is also the home of Tucki P7". It is not difficult to see that the new car positioning is comfortable family travel, while Tucki P7 insists on sports attributes.

Since comfort and space are very important for cars built for middle-class families, Tucki’s team also understood it this way, so that when He Xiaopeng pulled out 33 20-inch suitcases from the P7+ that was laid down in the back row, some critics criticized it, but Tucki didn’t take the initiative and rolled up storage space?

In my opinion, this is a harmless little teasing, because He Xiaopeng said from the beginning that Tucki P7+ has two important missions. First, let users feel the space and comfort of "luxury executive-class cars". Space is naturally the selling point of Tucki P7+, and it is reasonable to introduce it with pen and ink. Second, let fuel vehicle users experience the pleasure of "high-order intelligent electric shock" as standard, so the label of Tucki P7+ "the world’s first AI car" is playing very loudly, and the intelligent driving cabin can be regarded as Tucki, which will shake the confidence and long board of the home market.

Indeed, Tucki P7+ meets the needs of domestic family cars: for example, Tucki P7+ has a length of more than 5 meters and a wheelbase of 3 meters, which is the standard C-class car positioning; Tucki P7+ used the thinnest 800V battery pack in the industry, and combined with CTB body battery integration technology, the head space of the second row was 973mm, which is rarely seen in the pure electric car market.

Compared with Tucki P7, Tucki P7+ has a full and smooth body side and a borderless door design. However, the tail is made of a slip-back shape, and the design of a suspended roof and a double-layer tail is ingenious. The blackened upper tail is integrated with the car, and the whole tail is a hatchback shape, so the drag coefficient of the whole car is reduced to 0.206Cd, laying the foundation for the minimum power consumption of 11.6kWh per 100 kilometers.

If you like the GT with a slip back, Tucki P7+ does not fall into the conventional shape, which is really worthy of attention. The hatchback is not only concave in shape, but also gains a lot of storage space. The largest 725L trunk in its class has an 83L storage compartment under the trunk cover. The hatchback trunk door has a large opening angle, and the height also supports customization, which is convenient for users to load large luggage.

In terms of comfort and driving entertainment, Tucki P7+ also shows a "family-oriented" side. The interior is covered with a large number of soft materials. The heating, ventilation and massage of the whole seat are standard, and the back row is equipped with the same driver’s desk. The 15.6-inch floating touch screen in the front row has a resolution of 2.5K, and the Qualcomm SA8295P chip. As for the 8-inch entertainment control screen on the rear air outlet, it also supports the requirements of two rows of air conditioners, seats, co-pilot boss key, music and video.

Let’s look at the intelligent cabin intelligent driving. The word "standard" is very frequent. After all, it will bring "electric shock" to fuel car users. He Xiaopeng described it this way: "I can tell you with great confidence that Tucki’s intellectual driving level will have a brand-new leap in P7+, and conservatively, it will double."

Tucki P7+ is equipped with Tucki AI Hawkeye Vision Scheme. Compared with the lidar scheme, the perceived distance is increased by 125% and the recognition speed is increased by 40%. P7+ comes standard with two Orin-X intelligent driving chips, with a single computing power of 508TOPS, which is the AI Hawkeye vision scheme and the first single-pixel Lofic architecture in the industry.

Tucki P7+ will also launch Tianji 5.4.0 system. The upgraded contents include: XNGP supports 0-speed activation and in-situ startup. In addition, this function can be used when P7+ is delivered. This is also the first time in the industry to fully apply the AI-based operating system and fully access the Tucki self-developed X-GPT model. From the perspective of car use, the addition of AI means many OTA iterations of vehicles. One day, it was found that the chassis, sound and driving mode were better than before. There is also a small bright spot. The borderless rearview mirror of P7+ is also ingenious. The AI intelligent driving indicator light is integrated in the base. When the intelligent driving is turned on, the blue-green light is always on. I don’t know if this will be the standard for Tucki models, but Tucki has great confidence in smart driving.

In terms of power, the first show of Tucki P7+ didn’t focus on communication, but it is reported that Tucki P7+ is a single motor version, which will be equipped with different sizes. The battery capacity is 60.7kWh, the pure battery life of CLTC is 602km, and the maximum output power is 180kW；. The CLTC version with a capacity of 76.3kWh has a pure electric cruising range of 710km and a maximum output power of 230kW. The chassis is equipped with a front double wishbone and a rear five-bar independent suspension.

Write at the end:

I thought that He Xiaopeng would announce the pre-sale price on the first show of the new car. After all, it is also good to let Tucki P7+ have a wave of existence while MONA M03 delivered over 10,000 in the first month. As a matter of fact, the Tucki team has a bigger goal. Tucki P7+ is a global model, which will be launched at the Paris Motor Show in a few days, and the pre-sale price will be announced. In late October, the national store will test drive, and it is planned to be launched in November, and it will be delivered as soon as it is launched. He Xiaopeng also "emphasized" that the production capacity of Tucki P7+ will not be a problem. MONA 03 has already increased its production capacity twice in the first month, while Tucki P7+ has also completed trial-production and climbing, and has been mass-produced and stocked in advance.

From the known product configuration, this Tucki P7+ which focuses on intelligence, comfort and space will be positioned no lower than Tucki P7. Although there is no laser radar, it is equipped with the most advanced vision scheme in Tucki, and the power consumption is also very affordable. The family car scene is "both necessary and desirable", and the maximum space, strong bearing capacity and seat comfort are all met one by one.?

There is no doubt that Tucki P7+ is well-prepared to penetrate the home market, but the 200,000-300,000-class track is not just Model 3, but a situation in which a hundred schools of thought contend. Now, the fighting capacity of Tucki P7+ is only the lower limit of the competition qualification, and the upper limit depends on the configuration and price. At the first show conference, He Xiaopeng didn’t say anything about pricing, but he revealed that the P7+ was the first model in Tucki to achieve the goal of reducing the technical cost by 25%, while investors hoped that the gross profit margin of this car would be above 20%.

Combined with the reality that the same level has become a red sea, the sales scale of Tucki P7+ must be improved to achieve the purpose of "reducing costs and increasing efficiency", which almost determines that the new car needs a very competitive price. Will Tucki P7+ be like Mona M03, and will there be any surprises in pricing? I think He Xiaopeng wants an "explosive price" more than potential users.

The original Li Qingchao returned to the park and was included in the topic # Virus Supertalk 5.

Herpes virus is one of the most widely distributed viruses in human beings, and it can not be eliminated by human body, which will harass you for life and even give you a fatal blow. What’s more, herpes virus is hard to prevent, so we have to be prepared for the onset, and some preparations are particularly important.

Have a sexual partner? Have pets? Have a baby? Are you pregnant? Old? Have other immune diseases? (Nothing is contagious …) Please read aloud and recite the full text with emotion to find out.

Author | Li Qingchao (Shandong Normal University)

People generally refer to small things, problems and troubles as "little kiss case", and our people also have a saying called "little bubble". Small blisters refer to blisters or pustules on the skin or mucosa, which can be caused by burns or infections. In this issue, we introduce a kind of "blister-loving" virus: herpesviruses.

The word "herpes" comes from the Greek word "herpein", which describes the feeling that insects crawl slowly on the skin and is extended to "spread". Common lip blistering is often a herpes attack, and chickenpox, which is itchy and painful and can’t be scratched, is also a ghost of herpes virus. Of course, you may have heard of these. However, the distribution of herpes virus is much wider and more kinds than you think, and the possible consequences of ordinary "small bubbles" are much more serious than you think. Dr. House once diagnosed a case of encephalitis caused by herpes simplex virus.

Figure 1. Although this line is not o(╯□╰)o 丨 from House, S02E19.

On the occasion of a beautiful holiday, we mainly pay attention to those little bubbles in sexual life, as well as those that will exist without sexual life, and then get to know their brothers and sisters.

Herpes virus: the virus in you.

Herpes virus is a large class of enveloped viruses with double-stranded linear DNA genome (Figure 1), which can be divided into three subfamilies: α, β or γ, and 107 species have been confirmed (data of ICTV in 2019). There are 8 kinds of Human herpesvirus (HHV) that can infect people (HHV1~8), among which HHV1~5 is the most common herpes virus in people, and more than 90% of adults are infected with at least one kind. They mainly cause spreading vesicular lesions on skin or mucosa (HHV1~3), and also cause symptoms such as mononucleosis, nasopharyngeal carcinoma and retinopathy (HHV4~5).

Figure 2: Typical Structure of Herpes Virus: Ekaterina E. Heldwein, Science, 2018

Herpes virus infection is characterized by ① high infection rate, ② latent infection, ③ lifelong infection, incurable, ④ repeated activation, ⑤ inconspicuous infection symptoms and ⑤ opportunistic infection.

The so-called latent infection means that the virus exists in a hidden form or dormant state in the human body, and it hardly replicates and does not cause infection symptoms.

Latent infection is the reason why herpes virus cannot be cured. Herpes virus, a habit of "I’ll go in, I won’t move around", makes it difficult for the immune system to detect it, does not trigger an immune response, and cannot be eliminated by the immune system. In this way, the herpes virus can stay in the human body for a long time. So far, there is no antiviral drug or vaccine that can completely eliminate herpes virus in infected people.

Of course, herpes virus is not always in a latent state. When other pathogens are infected, or suffer from strong sunlight stimulation (such as sunburn), and the immunity is low, herpes virus can remove the latent infection state and enter the active replication period, causing diseases such as herpes. Moreover, this activation process can occur repeatedly in infected people, leading to repeated illness of virus carriers. Some opportunistic herpes viruses themselves can further weaken human immunity and lead to more serious diseases.

"Life lies in stillness". Herpes virus successfully infects and exists in billions of people with a "low-key" survival philosophy, waiting for an opportunity. When the beautiful holiday is coming, let’s pay attention to those little bubbles in sexual life first.

Herpes simplex virus type Ⅱ

Herpes Simplex Virus 2（HSV-2）

Herpes grows on the genitals and is called genital herpes. It is a common sexually transmitted infection (), and the main pathogen is herpes simplex virus II (HSV-2/HHV-2). It is estimated that about 846 million people (12% of the world’s population) suffer from genital herpes (The Lancet data in 2016).

After HSV-2 infection, most people have no symptoms or mild symptoms, so they don’t know that they have been infected at all. Generally, it occurs 4 days after contact with the source of infection, and the symptoms can last for 4 weeks. Small, single or patches of blisters will appear in the external genitalia and around the genitals, anus and perianal region, and painful ulcers and herpes sores will be formed after the blisters burst.

During the onset, it may be accompanied by symptoms such as fever, pain or swollen inguinal lymph nodes. In rare cases, there will be symptoms such as painful urination, dysuria, cervicitis and proctitis.

After the first attack, about 80% people will relapse, with an average recurrence of 4 to 6 times a year. The first attack is often the most serious, and it usually takes 2~3 weeks to fully recover. Recurrence is usually mild and can be recovered within a few days.

Genital herpes mainly goes through the following stages:

There is a tingling or itching sensation in the affected area, which usually occurs within 12 to 24 hours after the onset of the disease.

A single or sheet-like liquid-filled blister is generated.

Blisters burst and become herpes sores or ulcers.

The sore surface or ulcer indicates that the scab is dry and finally healed.

Figure 3: HSV-2 and genital herpes, herpes genital tips

HSV-2 is transmitted through kissing and skin contact, and can also be transmitted from person to person through vaginal, oral or anal sexual intercourse. In a word, if your skin or genitals come into contact with the secretions of infected people, you may be infected. Therefore, the risk of sexual transmission of HSV-2 is one in a thousand, and the risk of transmission between husband and wife is about 7.5% every year. Using condoms can reduce the risk of HSV-2 infection by half.

There is no vaccine for HSV-2 at present. It can be prevented according to the preventive measures of sexually transmitted diseases, but as mentioned above, condoms can only partially reduce the risk. If herpes is found in vulva, anus and surrounding areas, you should go out for an excuse and evacuate the scene to avoid sexual contact. Because visible skin or mucosal blisters and ulcers can produce a large number of viruses.

However, even if the infected person has no symptoms and no skin sores, his mucosa can release the virus (reproductive tract secretions are poisonous), and there is still a risk of transmission.

TIP！

Herpes cannot spread through the surface of toilet seats and other objects, because the survival ability of herpes virus after leaving the human body is very poor.

Mothers infected with HSV-2 can transmit it to their newborns through vertical transmission. During childbirth, the virus can infect the skin, mouth, lungs or eyes of newborns. If the virus spreads in the uterus, it may even lead to serious infection of the brain and other important organs of the fetus. However, if the mother has no symptoms or blisters during childbirth, the risk of infection transmission is extremely small.

If the mother is infected with HSV-2 in the late pregnancy, the risk of vertical transmission is greater. Therefore, it is suggested that women with genital herpes should take antiviral drugs in the last few weeks of pregnancy before delivery, and pregnant women with obvious ulcers during delivery should be encouraged to have caesarean section to prevent HSV-2 from being transmitted to newborns. If the newborn is infected with herpes, it needs to be treated by intravenous antiviral drugs.

When people with genital herpes are naturally exposed to HIV, the risk of HIV infection is estimated to increase by two to four times. This is because the ulcer caused by herpes infection or the damage of skin and mucosa (oral cavity, vagina and rectal intima) may damage the protective effect of skin and mucosa. HSV infection can also increase the number of CD4 cells in genital mucosa, and HIV can invade these cells.

Similarly, if HIV-infected people suffer from genital herpes at the same time, they are more likely to spread HIV to others. In people who are co-infected with HIV and HSV, the replication, activation and release of HIV in genital herpes infection sites will increase the risk of HIV transmission to sexual partners.

HSV-2 cannot be cleared. When genital herpes occurs, oral antiviral drugs can be used for treatment, including valaciclovir, famciclovir and acyclovir. Severe patients should be given acyclovir intravenously. Although these antiviral drugs can not eliminate herpes virus infection, they can reduce the severity of symptoms and shorten the duration of symptoms. The first attack or recurrence should be treated as soon as possible. Taking antiviral drugs every day can reduce the frequency and severity of recurrence and reduce the risk of transmitting the virus to sexual partners.

TIP！

Pre-pregnancy examination can choose to detect herpes simplex virus.

Herpes simplex virus type I

Herpes Simplex Virus 1（HSV-1）

Now, let’s take our eyes back from our crotch and look at our lips in the mirror. Is there a "fire knot"? When winter comes, many people will grow some small blisters or sores around their lips, which is a typical symptom caused by herpes simplex virus type I (HSV-1/HHV-1): Herpes labialis (Figure 4), commonly known as getting angry.

Figure 4: Cold sores, eye herpes, herpetic keratitis, facial herpes, gingival herpes and finger herpes caused by HSV-1 infection | Source: wikipedia.

According to the latest research, it is estimated that there are billions of people suffering from cold sores in the world, among whom 67% are infected with HSV-1, which is equivalent to 3.7 billion people.

I don’t need to tell you the symptoms of cold sores infected by HSV-1, as you know: burning pain, small blisters, and sore surface damage. Cold sores usually heal in about two weeks, but they will recur. Let’s see what the virus did during the onset:

Figure 5: Onset stage of cold sores (click to enlarge) Alex Semprini1 et al., BMJ, 2019.

From the prodromal stage to the blister stage (day 0~3), the virus did not cause an open sore surface. At this stage, antiviral ointment can be used to suppress the deterioration of the disease. You can consider using ointment containing antiviral components such as valaciclovir and acyclovir and hydrocortisone.

From the blistering stage to the healing stage (day 2-14), an open sore surface has been caused, and the liquid on the sore surface contains a lot of viruses. At this stage, you should avoid picking by hand to prevent the disease from getting worse or secondary bacterial infection, and don’t scratch other parts of the body after picking herpes.

During the onset of cold sores, you should avoid eating spicy, greasy or heavy-tasting food, and don’t eat citrus fruits to avoid irritating the wound.

In fact, "cold sore" is a symptom name, and HSV-1 can also occur in other parts-in the eyes, it is called peripheral herpes (even herpetic keratitis), in the face, it is called facial herpes, in the hands, it is called herpes gingivitis in the gums (the first infection is easy to occur), and it can be herpetic angina in the throat …

HSV-1 can also cause genital herpes, but that is not a typical symptom of HSV-1.

In most cases, HSV-1 is asymptomatic after infection, but lurks in the trigeminal ganglion-just above the auricle (Figure 6). Psychological stress, menstruation, sunburn, fever, dehydration or local skin trauma may reactivate HSV-1. Dental or neurosurgical operations, lip tattoos or dermabrasion are also common causes.

The activated virus can spread again, then actively migrate to the primary infection site (usually lips or eyes) and replicate, causing cold sores or herpetic keratitis. Virus particles produced after activation can also reach the brain, causing a rare but serious diffuse acute brain infection, namely herpes simplex encephalitis (Figure 6).

Fig. 6: Latency and activation of HSV-1. Note that the trigeminal ganglion is just above the auricle. (Click to enlarge) | Source: Trends in Microbiology

HSV-1 is mainly transmitted through oral mucosa or damaged skin contact with body fluids containing virus. Therefore, we should not share things that come into contact with the oral cavity, such as toothbrushes and water cups, and avoid close contact with others (avoid kissing, oral sex or excessive physical collision).

If you have cold sores, we should avoid touching the sore surface and wash our hands frequently during the onset. Because cold sores can spread to other parts of the body through fingers, such as eyes, skin or fingers, this process is called "self-inoculation". Finger infection may occur when children with cold sores or primary HSV-1 infection suck their fingers. Therefore, even if you have been infected with herpes virus, you should avoid spreading herpes to other parts of your body.

HSV-1 causes this kind of "small blister", and there are many infected people, but the symptoms are not serious. At present, there is no treatment or vaccine for this virus.

Attention! !

"caring for each other" can describe the deep affection between husband and wife, and "caring for grandchildren" is the joy of grandparents and grandchildren. I don’t care about the affairs of adults, and I can’t manage them. When it comes to infants, I still have to emphasize two words: I must avoid contact with strangers, let alone kiss (Figure 7). Resolutely put an end to the bad habit of chewing food and feeding babies! Ouch! Not even parents, not at all!

Figure 7: Poor baby reminds you: Don’t kiss blindly | Source: theAsianparent.com

Chickenpox-herpes zoster virus

Varicella-Zoster Virus（VZV）

Next, let’s look back on the past and learn about varicella-zoster virus (VZV/HHV-3) from the long river of time. VZV is also our old friend, and it can even be said that it has not been seen for many years. When I was a child, I met it, and it was called chickenpox. When I saw it when I grew up, it drifted away. It was called "waist-bound dragon", "snake’s disk sore", "spider’s sore" and "snake Dan" … In fact, its original name was herpes zoster.

Children, teenagers and young people are infected with VZV, which causes chickenpox, while adults infected with VZV often cause herpes zoster. VZV has a wide range of influences. In 2013, there were 140 million cases of varicella and herpes zoster worldwide (reported by The Lancet in 2015), which caused thousands of deaths every year.

The first time we fell in love with this virus was in the respiratory tract.

Primary VZV infection begins with epithelial cells of upper respiratory mucosa, and then spreads to tonsils and other local lymphoid tissues. Infected T cells can spread the virus to the skin through blood transportation from these lymphoid tissues, causing herpes zoster distributed all over the body.

During the primary infection, the virus is transported reversely from the infected skin along the nerve axon, or the virus is brought into the sensory neuron cells of the ganglion through T cells, and a latent infection is established in the dorsal root ganglion. After virus replication is reactivated, VZV can re-enter skin cells via anterograde axon transport, causing herpes zoster (Figure 8).

The skin lesions and leachate of chickenpox and herpes zoster contain high concentrations of infectious viruses, so they are easily transmitted to susceptible people.

Figure 8. VZV infection process and symptoms (click to enlarge) | Source: Cleveland Clinic

Chickenpox in children usually begins to appear 10 to 21 days after being infected with the virus. Early symptoms include nausea, loss of appetite, muscle aches and headaches, and then chicken pox on the chest, back and face until it spreads all over the body (Figure 8). Other symptoms include fever and fatigue, and may also cause symptoms such as pneumonia, encephalitis and bacterial dermatosis, which last for about a week.

The symptoms of chickenpox infection in teenagers are more serious than those in children. The consequences of infection in pregnant women are more serious. The virus may spread through the placenta and infect the fetus, resulting in fetal malformation, congenital varicella syndrome or premature delivery.

If the child has chickenpox, the following methods can be used for care:

Use a cool and clean wet towel or bathe in warm water to relieve skin itching and discomfort.

Dry your body by patting it with a dry towel, and don’t rub it to prevent the chickenpox from bursting.

Use calamine lotion (avoid face) and analgesic cream when necessary.

Trim nails and keep them clean, and put gloves on your child before going to bed to avoid scratches.

If you have chicken pox in your mouth, you need to eat cool, soft and light food, and avoid eating sour, salty, hot and spicy food.

If the condition is serious, you need to seek medical advice in time.

When you are old, immunosuppressed or immunocompromised, VZV lurking in the body is easy to activate and then come out as a demon-this is Shingles.

When herpes zoster comes on, it will produce a wide herpes band on the face or one side of the body, which is full of blisters and rashes, stinging or painful, and some people will have fever, pain and feel tired. The rash usually heals within 2-4 weeks.

Some people will have nerve pain symptoms similar to electric shock or burn for months or years after the recovery of herpes zoster. This situation is called "postherpetic neuralgia", which is nerve damage caused by VZV, and it is easy to occur in people with low immunity such as the elderly. It is estimated that there is a 1/3 chance of suffering from herpes zoster in a person’s life, which is more common in the old age (the annual incidence rate of people over 65 is about 1%) and generally does not recur.

The onset of herpes zoster will produce a red band-shaped herpes on one side of the body, and it is often accompanied by severe pain. It is rumored in Jianghu that "if this dragon/snake wraps around its waist, people will die", but fortunately, my waist is thick.

. Obviously, this is nonsense. I assure you that herpes zoster rarely grows in a full circle, because VZV lurks in the dorsal root ganglion, and the herpes after activation is limited to the corresponding skin segment. The so-called skin section refers to the skin area dominated by various spinal nerves, which is distributed up and down in the human trunk and separated from the left and right (Figure 9). However, VZV does have a certain lethality, causing about 6,000 deaths every year (The Lancet reported in 2016).

Fig. 9: Distribution of skin segments of human upper body. Herpes zoster only occurs in the corresponding skin segments in the latent area | Source: wikipedia.

Different from herpes simplex virus HSV, VZV is an air-borne disease with strong transmission ability. An infected person can spread to another person with a sneeze/cough. Chickenpox or herpes zoster can also spread through contact with the skin surface with herpes from 1-2 days before it appears until herpes scabs.

At present, there are vaccines against VZV, and some areas in China have been included in the immunization program. . Injection of VZV vaccine will reduce the incidence of chickenpox and herpes zoster, and more importantly, even if you have chickenpox or herpes zoster, the vaccine can greatly reduce the proportion of moderate and severe patients.

VZV vaccine is not suitable for pregnant women, tuberculosis patients, people with low immunity and immunosuppression, and allergens should be tested before vaccination. It should be noted that once a family member has been vaccinated with VZV, personally, it is suggested that all close family members should be vaccinated together. The low VZV vaccination rate may increase the risk of herpes zoster among unvaccinated people. Because the VZV vaccine currently used is an attenuated live vaccine.

After getting chickenpox or herpes zoster, you need to take care of your skin carefully to prevent secondary infection. In severe cases, you can use analgesics, antiviral drugs and steroids. Be careful not to take aspirin (acetylsalicylic acid) when you are suffering from chickenpox or herpes zoster, and when you are vaccinated with VZV, because aspirin will increase the risk of Reye’s syndrome caused by VZV-Reye’s syndrome is a rapidly deteriorating brain disease with brain dysfunction such as persistent vomiting, extreme sleepiness or aggressive behavior.

Other herpes viruses

Finally, let’s take a look at several other common people infected with herpes virus. Their common feature is still: if you are infected, you will never want to get rid of it. When your immunity is weak, you must make waves.

Epstein-Barr Virus (EBV/HHV-4) is one of the most commonly infected viruses. Its spread is somewhat similar to HSV-1. It is generally spread through saliva, and it has the nickname of "the kissing disease". It can also be spread by sharing food, drinks and dental utensils. Of course, EBV also exists in other body fluids. Infection often occurs in infants and young children. Half of the children under the age of six have been infected with EBV, and more than 90% of the people in adulthood have been infected with EBV.

EBV generally infects B cells and epithelial cells, and can lurk in B cells for life. Under the conditions of overwork, nutritional deficiency, excessive sadness, hormone fluctuation (puberty, pregnancy, menopause) and childbirth, EBV can be activated, thus causing diseases.

Children infected with EBV often have no symptoms. When adolescents or adults are infected with EBV, there is a 35% to 50% chance of causing infectious mononucleosis, resulting in fatigue, fever, pharyngitis, lymphadenopathy, hepatosplenomegaly, rash and other symptoms. EBV infection is related to malignant tumors such as lymphoma, gastric cancer and nasopharyngeal carcinoma, and autoimmune diseases such as multiple sclerosis. At present, there is no good means of prevention and treatment. The central idea is to keep yourself healthy, in good health and strong immunity, so these viruses will not be evil.

Human Cytomegalo Virus (HCMV/HHV-5) is a type β herpes virus, which mainly infects salivary glands, but also infects other parts of the body. Infectious HCMV may exist in any body fluid of the infected person, and it can be transmitted vertically through contact with the infected body fluid. There is a 90% probability of being infected with HCMV in a person’s life. After infection, HCMV lurks in the human body and can be reactivated at any time. HCMV infection is usually rare and almost undetectable in healthy people, but it may be life-threatening for people with low immune function:

Newborns: Vertical transmission of HCMV is one of the common causes of neonatal abnormalities. If the mother is infected with HCMV for the first time during pregnancy, the newborn may have symptoms such as light weight, microcephaly and epilepsy. Even if there are no symptoms, there may be problems in hearing, mental and motor coordination in the future. Newborn parents and babysitters should maintain their own hygiene habits and minimize the risk of transmitting the virus to newborns.

Adults with low immunity, such as HIV-infected people, severely burned people or organ transplant recipients, may get sick because of the reactivation of HCMV, and have symptoms such as retinitis, pneumonia and colitis. Antiviral drugs can be used for prevention and treatment.

Adults with normal immunity are rarely affected by HCMV, but the virus can also cause mononucleosis and increase the risk of diabetes, cardiovascular disease and cancer.

Roseolovirus, including HHV-6 and HHV-7, can cause infant roseola, also known as infantile rash (known to old mothers), which is a very common mild infection. Generally, it doesn’t need treatment, and its symptoms are fever and rash, which lasts for about four days. If necessary, use antipyretics. If symptoms such as lethargy, persistent high fever and convulsions appear, you should seek medical attention in time.

Kaposi’s sarcoma-associated herpesvirus (KSHV/HHV-8) can be transmitted through saliva or sexual behavior, and the infection rate varies greatly from region to region, with about 10% of the population infected in China. KSHV infection is generally asymptomatic, but it causes Kaposi’s sarcoma, a local skin tumor, on the skin of AIDS patients.

Other animal herpesvirus that may infect people: Generally, human beings are rarely infected with herpesvirus carried by animals, but for high-risk specific groups such as animal breeders, laboratory animals, users and veterinarians, attention should be paid to preventing animal herpesvirus infection. Monkey B virus is a herpes virus carried by monkeys. Monkeys have no symptoms, but it is fatal to people. Don’t mess with monkeys. Pseudorabies virus is a common animal herpes virus, which can infect pigs, cattle, sheep and other domestic animals. Recently, it has also been reported that it can infect people and cause serious encephalitis.

Conclusion

Ask: "oh, my god! There are so many hateful "tenants" on my poor little body except the disgusting fat. I feel dirty. What should I do?

A: "live well, after all, there are very few people who are not infected." Knowing so much knowledge doesn’t make you suspicious and worry too much. What’s the use of worrying blindly? Most herpes viruses are really "small bubbles". Understanding these viruses is to know how to prevent them, how to deal with symptoms, restore health as soon as possible, and avoid the most serious situation. People in rivers and lakes, the world of mortals, HHV-1, HHV-2, HHV-3, HHV-4, HHV-5, HHV-6 and HHV-7 keep us alive.

reference data

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Original title: "Once the infection recurs for life, the most difficult virus in history has captured 90% of the world’s population. When it is discovered during sexual life, it must be stopped in time."

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