Help you dig out the ＂feeding＂ diet food for health.

　　Recently, some media reported that online celebrity weight loss coffee cost 8 yuan, but it sold for 298 yuan. What is even more exasperating, however, is that coffee is actually a diet drug that was withdrawn from the market 10 years ago — — Sibutramine!

　　It’s almost the season of revealing meat, and it’s not too late to lose weight. Have you ever been tempted by those advertising slogans that advertise that you can lose weight quickly, burn fat instantly and lose 30 pounds a month? Pharmacists are here to remind you that those slimming foods such as slimming tea, weight loss coffee, and fat-burning capsules sold illegally are likely to contain drugs added illegally, which pose a health threat to the body. Don’t blind your eyes to all kinds of fancy weight-loss products, otherwise it is very likely that the more you lose weight, the worse your body will be.

　　What kind of "ghost" is sibutramine

　　Searching for "sibutramine" in Baidu, I found that sibutramine was added to many so-called diet foods. For example, "fat-burning slimming capsules", fruit and vegetable drinks (solid drinks) and fruit and vegetable slices with slimming effect.

　　Sibutramine is a central weight-loss drug, which can act on the central system, by inhibiting the reuptake of neurotransmitters such as norepinephrine, 5- hydroxytryptamine and dopamine in the body, so as to suppress appetite and reduce food intake to achieve the purpose of weight loss.

　　In 1997, it was approved for obesity in the United States, and it became a weight loss star for a while, so it was listed in China in 2000. After listing, China’s ADR center also monitored some adverse reactions, mainly headache, dry mouth, insomnia, dizziness and so on. In fact, it may not only affect the digestive system, nervous system, central and peripheral nervous system, cardiovascular system, etc., leading to endocrine and metabolic disorders, mental stress, sleep disorders and so on. But the most serious is the risk of myocardial infarction, stroke, cardiac arrest and so on, especially for patients with heart diseases such as coronary heart disease, arrhythmia, or already suffering from cerebrovascular diseases, the risk of cardiovascular and cerebrovascular accidents is higher.

　　In view of the fact that sibutramine may increase cardiovascular adverse events after marketing, in 2002, the European Union launched a large-scale clinical study on the influence of sibutramine on cardiovascular safety after marketing, which was called "Sibutramine Cardiovascular Terminal Test", including the participation of many countries and regions such as the European Union and Australia. The research results published in 2010 show that the use of this drug can increase the serious cardiovascular risk. Thus, since 2010, the United States, the European Union and China have successively withdrawn sibutramine from the market.

　　Those "ingredients" lurking in diet foods

　　At present, some illegal sales of slimming tea and weight loss coffee claim that the products are very safe while promoting slimming, which makes many consumers put down their defenses. But in fact, these weight-loss products are likely to have serious health risks. Because products that are generally claimed to have the effect of fast weight loss, in order to make consumers lose weight, it is very likely that some drugs will be added illegally, mainly in these categories:

　　The most common way is to add appetite suppressants such as sibutramine, fenfluramine and its derivatives. These drugs mainly act on the central system of the brain to "pretend" to be full, reduce appetite and lose weight, but long-term use may affect the function of the heart and lungs, and cause symptoms such as palpitation and dyspnea, and increase the risk of pulmonary hypertension, myocardial infarction and cardiac arrest.

　　Add some laxatives such as phenolphthalein tablets (guide tablets), bisacodyl, etc. Take bisacodyl as an example, it is an irritating laxative, but long-term use may lead to chronic diarrhea, hypokalemia, secondary aldosteronism, and even metabolic alkalosis, myasthenia, renal tubular injury and so on.

　　Add some drugs to increase energy consumption, such as levothyroxine sodium, ephedrine, pseudoephedrine, theophylline, and diuretics such as furosemide and bumetanide. These drugs seem to "lose weight" by increasing energy metabolism and discharging more water, but in fact they may only lose some water.

　　More importantly, taking these drugs without knowing it may bring harm to the body. For example, taking levothyroxine sodium for a long time may lead to drug-induced hyperthyroidism, and symptoms such as palpitation, emaciation and exophthalmos may occur. Excessive use of ephedrine, pseudoephedrine and theophylline may cause arrhythmia, anxiety and myocardial infarction, and excessive use of diuretics may cause electrolyte disorders such as low potassium and sodium.

　　Other added drugs and some other drugs have also been detected in weight loss products, including fluoxetine and sildenafil. Many illegal weight-loss products contain not only one illegally added drug, but also two or more.

　　Pharmacists give you a prescription for healthy weight loss.

　　So is there a "safe" diet pill that allows us to reduce the meat easily? The answer is: not really. There is no product that claims to be safe to lose weight. No weight loss product is effective and has no side effects. Only a healthy diet plus adequate and moderate exercise is the safest and most effective way to lose weight. Here are three tips for losing weight safely.

　　Before you lose weight, calculate your BMI index. The specific algorithm is to divide your weight (kg) by the square of your height (m). If it is less than 24kg/m2, you don’t need to lose weight. If you are not satisfied with your body shape, you can shape it through fitness. If it is between 24 and 24-28 kg/m2, it is overweight; Above 28 kg/m2, you are obese, and you need to reduce it if you are overweight or obese.

　　It is suggested that only by adhering to a scientific lifestyle for a long time can we maintain our weight and reduce the rebound. Friends who need to lose weight and want to lose weight can go to the nutrition department of the hospital, ask a professional dietitian to give an individualized recipe, and then choose the exercise that they like relatively and suit them, and insist on exercising for a certain time every day.

　　If you need help with drugs, you can choose orlistat. At present, in China, the only drug with obesity treatment indications and approved by National Medical Products Administration is orlistat. However, orlistat itself has some adverse reactions, such as oily stool, increased stool frequency, abdominal pain and flatulence, which may also lead to liver injury, so please use it under the guidance of a doctor or pharmacist.

　　In addition, if you have diabetes at the same time, you can also choose hypoglycemic drugs, such as liraglutide, dulaglutide, exenatide, etc. For example, liraglutide has also been approved in the United States to assist patients with BMI above 27kg/m2 to lose weight. In addition, some drugs such as Dapagliflozin and Kaglinide can reduce blood sugar and weight at the same time.

　　Although everyone loves beauty, the road to losing weight is long and difficult, and there is really no shortcut. Scientific weight loss is the king.

　　Text/Song Zhihui (Beijing Tongren Hospital)