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China People’s Congress Network News On the morning of December 25th, 2008, the Sixth Session of the 11th the National People’s Congress Standing Committee (NPCSC) reviewed the State Council’s report on the progress of water pollution prevention and control. Wang Sheng, deputy to the National People’s Congress, suggested in his speech:

First, we should strengthen and improve the cadre assessment mechanism. How to strengthen the assessment? To further implement the Scientific Outlook on Development, we must first increase the weight of energy-saving emission reduction and pollution control indicators in the performance evaluation of party and government cadres, and solve the long-standing phenomenon that party and government cadres are hard-working and soft-handed in grasping economic work and energy-saving emission reduction and pollution control. Recently, it was reported that jiangsu provincial party committee and the provincial government have done a lot of work in this respect, and incorporated Taihu Lake governance into the comprehensive index system of Scientific Outlook on Development implemented by relevant cities and counties as an important part of the performance evaluation of leading cadres at all levels along Taihu Lake. Through this evaluation system, a large number of enterprises around Taihu Lake were shut down and transferred, which made Taihu Lake governance have a good effect. Therefore, in this regard, I think it is necessary to strengthen the cadre assessment mechanism.

Second, we should strengthen the accountability of enterprises. Enterprises are actually the main body of pollution reduction, and now enterprises are often passively investigated in this respect, because enterprises want to maximize profits. How to stimulate the internal motivation of enterprises to save energy, reduce emissions and control pollution, and how to make enterprises consciously do a good job in this regard? It is to solve the problem of low illegal cost and high law-abiding cost of enterprises, so it is necessary to use an iron fist to control pollution and severely punish illegal acts of enterprises.

Third, we should strengthen education and guidance for farmers. Building a new socialist countryside needs blue sky and clear water, but the domestic pollution, garbage pollution and non-point source pollution in rural areas are very serious. On the one hand, farmers don’t know enough. On the other hand, the government has done a lot of good things to solve the drinking water problem in rural areas, which has made the drinking water in rural areas meet the safety standards, but it has also brought about another problem. Originally, farmers paid attention to the water in rivers and ditches because they wanted to drink it. Now that drinking water is safe, they pay less attention to the prevention and control of water pollution. Garbage is dumped into ditches and rivers. Now all rural areas are building new villages, and some rural areas are bagging garbage, but farmers’ understanding of water pollution and non-point source pollution should be solved. For example, the utilization rate of chemical fertilizers and pesticides is only 30%, that is to say, 70% of chemical fertilizers and pesticides rush into rivers and ditches, forming water pollution. Therefore, how to strengthen the guidance and help in this respect and improve farmers’ awareness of water pollution prevention and control? We should strengthen education, help farmers to use fertilizers and pesticides rationally, improve the utilization rate of fertilizers and pesticides, and solve non-point source pollution.

Fourth, we should strengthen the matching and improvement of policies and regulations. At present, it’s a bit chaotic for us to grasp water control, and to grasp this one and throw away that one. Therefore, it is necessary to play a chess game in the laws and regulations, and to have a chess game guiding ideology for the protection of key water basins, the prevention and control of urban residents’ water pollution and the prevention and control of rural water pollution. Strengthening the prevention and control of water pollution should be a systematic project. We now advocate that there is only one earth for human beings. There is so much water on the earth, but there is not much water really available for human consumption. How to solve the water pollution problem? Water is the source of life, which has a great relationship with the whole mankind. How to solve this systematic engineering problem? To implement legal responsibilities here, there must be a system of accountability, and at the same time, supervision should be strengthened. (Shen Juan)

1905 movie network news Produced and directed by Shanghai Animation Film Studio, the classic animation of China officially landed in major cinemas across the country on November 5th, and released a word-of-mouth special. Many viewers who had watched the premiere before spontaneously came to Amway after watching the film, saying that they didn’t know why it was one of the best China animations in the eyes of countless people until they watched the film. "The feeling of watching on the big screen is different", "Let the world know that this is the real China animation" and "Many things with China characteristics that we pursue are in this film".

Since the film was self-edited, the film "Tianshu Qitan 4K Commemorative Edition" has caused many hot discussions among netizens for its sincere display of China traditional culture. At the previous premiere, the deeply rooted role images, funny and humorous story contents and the beautiful national style of brush and ink landscapes were unanimously recommended by many peers in the industry and the media. With today’s release, the film, which was hailed as a "landmark", officially met the national audience on the big screen, and the four behind-the-scenes highlights were also announced one by one.

Aspect 1: Meeting with History Witness the significance of China’s animation inheritance after 38 years.

Thirty-eight years ago, the film was born, and the classics that condensed the efforts of countless artists were born. Fantastic ideas, profound China myths and stories, and extremely advanced role images have captured countless audiences. Today, it is still regarded as one of the best China animations by many people.

Thirty-eight years later, the film "Tianshu Qitan 4K Commemorative Edition" was released nationwide on November 5, spanning the long river of time, and this profound China animation once again entered the public’s field of vision. For the audience who have seen it, this restoration is a gift to let them go back to childhood, while for the audience who have not yet experienced it, this work can make them feel refreshed. Since the development of China animation, the inheritance and innovation behind it have always remained unchanged, and "The Wonder Tan in the Book of Heaven" is one of the important works that cannot be ignored in the development process. Today’s restoration and release is not only popular, but also a lesson from history.

Aspect 2: Talk to yourself and focus on the core of China’s animation "fantastic beauty"

As an animated feature film, the drawing process of "Tian Shu Qi Tan" is full of hardships. According to director Yunda Qian’s recollection, painters judged the time required for the characters’ lines by lip-synching with stopwatches, so as to draw the corresponding mouth shapes of the characters. Painters worked overtime day and night, painting for three years, and finally created this classic in the history of China animation with perseverance and talent. Different from the image of "Gao Daquan" created by mainstream literary and artistic works at that time, "Tian Shu Qi Tan" focuses on the unique aesthetics of strangeness, interest and beauty. The unique character modeling and imaginative strangeness, vivid and three-dimensional interest of various characters and beauty of national art and culture in the film fully show the creative core of China animation.

Famous media people and writers once praised the film’s "family fun" characteristics at its premiere. She sincerely recommended all the audience to take their children into the cinema to watch, and said that the best parent-child relationship is to take their children to watch cartoons they watched as children. The famous film and television director also recalled his childhood fun after watching the film. He once put a cake on his head like an egg. Sometimes the pleasure brought by the film is not only the movie itself, but also the memory and emotion it brings. Well-known film and television actors said that they were very honored to see it in the cinema, and they had no regrets in their childhood.

Aspect 3: Coexistence with the Times, Advanced Interest Adapting to the Choice of Watching Movies for All Ages

The simple but not simple storyline and vivid and interesting character images of "The Wonderful Tale of Heaven" show us the unique features of the Chinese nation, so that folk art, ancient myths and national wisdom can be presented and passed down in the form of animation. Audiences of all ages can find childlike innocence and fun in the film, such as the strange-looking fox mother, which left an indelible impression on many people’s hearts after 70 s and 80 s. For the first-time audience, many plots in the film are attractive enough, such as the cornucopia constantly "copying" dad’s famous scenes, etc. In the previous advance viewing, many people said that "it was the first time I saw it, and it was very novel and fun", which proved that its story content is still out of date and timeless, and it can not only enjoy the visual baptism of the beautiful national scenery, but also appreciate many excellent traditional cultures.

Aspect 4: Blending with the nation and carrying forward China’s excellent traditional culture have a long way to go.

Today, with the prevalence of multiculturalism, many excellent works have emerged in the animation market at home and abroad. The restoration and release of "The Wonder of Heaven" has made many people start to think about the significance of China’s animation. China’s 5,000-year-old civilization has provided a good cornerstone for China’s animation creation. With its unique style and perspective, China Animation School has a special place in the world animation stage, which highlights the fine tradition of China culture and has its own unique national characteristics.

As one of the representative works of China School, the film "The Wonder of Heaven" draws lessons from the artistic elements such as paintings, sculptures, toys and operas in China’s traditional culture, and brings together many folk images, such as a large number of folk music used as background music, and the little emperor marveled at the "birds flying at the phoenix", walking on stilts, dancing dragons and lions and other folk activities, which can be described as a "folk grand view garden". The modeling of the three foxes draws lessons from the traditional Chinese opera facial makeup, which makes the audience unforgettable; The gardens, palaces, courtyards and mountains and rivers in the film follow the "wu school" style, drawing the human landscape with meticulous brushwork and heavy colors, and drawing the natural landscape with elegant ink and wash. The revisiting and attaching importance to the "China School" is, on the one hand, to commemorate the forgetfulness, and, on the other hand, to take history as a mirror to arouse the rethinking of nationalization in China’s animation creation.

The 4K Commemorative Edition of Tian Shu Qi Tan officially landed on the national big screen on November 5, and the classic is full of vitality of the times. I believe it will bring an excellent viewing experience that cannot be missed to many audiences!

Housing prices in first-tier cities skyrocketed at the beginning of the year.

The property market in early 2016 is very similar to the stock market in early 2015. Everyone talks about stocks and everyone talks about houses. Housing prices in first-tier cities have gone up like a runaway, and Shanghai has even seen a price jump of 700,000 a day. At the same time, the scene of buying a house is no less than the double eleven.

In Shanghai, Lujin Shanghai School attracted nearly 100 buyers to queue up overnight in the middle of the night before the opening, and even friends in the team came wrapped in quilts, which surprised many people in the industry.

In Hangzhou, the second phase of Yangliu County in Greentown opened, and even 1000 people grabbed the source of 388 suites.

In Guangzhou, Vanke Mountain View City, which was just the opening time before, couldn’t wait to push it after the holiday, and it was robbed half an hour after the opening.

In addition to the bursting of real estate, the real estate trading center is also overcrowded, and Shanghai Baoshan Trading Center has to implement current-limiting measures.

On the one hand, the real estate in first-tier cities is an ideal haven, and safe-haven investment has become the most direct factor to promote this round of skyrocketing. On the other hand, at the beginning of this year, the central bank lowered the down payment ratio, and social funds also participated. The loose credit policy provided financial solutions for buyers, and financial services similar to "down payment loans" also boosted the rise of housing prices to some extent.

De-leverage the property market and strictly control the "down payment loan"

The so-called down payment loan refers to the fact that when the down payment funds of buyers are insufficient, real estate agents or financial institutions can provide them with subsidy funds for borrowing, which can be used by buyers to enlarge the leverage of buying houses. In some areas where house prices are rising rapidly, the existence of down payment loan has reduced the actual down payment of some buyers to 10%, which is equivalent to 10 times the leverage, and the leverage ratio is much higher than the "off-site fund-raising" at the peak of the stock market last year.

With the skyrocketing housing prices in first-tier cities, "down payment loans" began to surface, attracting the attention of the regulatory authorities. Shenzhen was the first to take the shot. In March this year, Shenzhen Financial Office issued a letter to prevent financial risks in the real estate industry, requiring Internet finance associations and small loan associations to investigate the situation of leveraged lending by enterprises under their jurisdiction and sort out the product model and the amount involved. At the same time, Guangzhou also began to investigate P2P and small loan companies to issue down payment loans.

A regulatory storm against leveraged funds represented by "down payment loans" is coming. If house prices continue to rise, using leverage may make a lot of money; Once house prices fall, there may be "trampling". If the high leverage of housing market is allowed to continue, it will be a financial disaster.

Real estate in first-tier cities is overheated, and the government urgently regulates it.

On March 25th, the Shanghai Municipal Government promulgated "Several Opinions on Promoting the Stable and Healthy Development of the Real Estate Market" to strictly control the property market, among which the most stringent provisions include: "Non-registered households in this city must pay social security for five years or more; For households with a set of housing, the down payment ratio for purchasing improved ordinary self-occupied housing has increased to 50%, and the down payment ratio for purchasing non-ordinary housing has increased to 70%. "

This regulation policy is called the strictest regulation in Shanghai. Coincidentally, Shenzhen has also introduced a regulation policy: non-deep households buy houses in Shenzhen, and the social security payment period is increased from the previous year to three years; The first suite paid off the mortgage, and when buying the second suite, the down payment was increased from 30% to 40%.

Under the strict control policy, the transaction volume of housing prices in Shanghai and Shenzhen dropped sharply, followed by the sale of some properties at reduced prices. Different from Shanghai and Shenzhen, due to the crowding-out effect of regulation, the property market in second-tier cities, such as Suzhou and Nanjing, began to boom, and the transaction volume and transaction price rose.

The expiration of some real estate land use years in Wenzhou has aroused the concern of the whole people.

In April this year, some citizens in Wenzhou were unable to conduct normal transactions when buying and selling second-hand houses. The reason was that the land had expired, and they had to pay hundreds of thousands of yuan of land transfer fees to re-apply for land certificates. They spent millions of yuan to buy houses, and they had to pay a lot of money after the expiration. After our house expires, we have to spend a lot of money to renew it, which has aroused heated discussion and concern from all walks of life.

The property right of the house we live in is divided into two parts, one is the house ownership, which is permanent, and the other is the land ownership. The right to use residential land is generally 70 years, which is also a controversial place.

What should I do if the property right expires after 70 years? According to the relevant provisions in the Property Law, the house is "automatically renewed" when it expires, but it has never been said that this is automatically free.

On the morning of December 23rd, Wang Guanghua, Vice Minister of the Ministry of Land and Resources, said that there was no need to apply for renewal, charge no fees, and handle the transaction and registration procedures normally, which was a clear solution. However, Wang Guanghua also mentioned that this is a transitional approach, and the formal approach has to wait for the introduction of relevant legal arrangements.

There are frequent land kings in first-and second-tier cities, and the price of "flour" is higher than that of "bread"

In May this year, the land market in Shanghai ushered in the first land transfer after the regulation of "Shanghai Nine Articles". The three plots of land in Fengxian and Songjiang all had a premium of more than 100%. The floor price of the two plots in Songjiang was close to 40,000/square meter, and the guaranteed price was 60,000/square meter, which was higher than the regional house price. A week later, the Zhou Pu plot was auctioned, with a floor price of 54,500/m2 and a guaranteed price of 79,000/m2. Similarly, in Nanjing, Hangzhou, Xiamen and Hefei, there have been cases of high premium land acquisition.

Developers seem to be crazy about taking land, the main reason is that they are worried about the future land supply. Take Shanghai as an example, Shanghai has locked up 3,226 square kilometers of construction land, and by 2013, 3,070 square kilometers have been used, leaving less than 156 square kilometers (including business and industry) in the future. Therefore, the scarcity of land in Shanghai has reached an unimaginable level. Coupled with the downturn of the real economy, the real estate market has become a safe haven for wealth.

Shanghai exploded rumors of the new mortgage policy, and divorced people crowded into the Civil Affairs Bureau.

At the end of August, a crazy divorce tide was staged in Shanghai. Divorced people crowded the civil affairs bureaus, and some civil affairs bureaus had no choice but to start limiting the number. Shanghai people’s desperate divorce stems from a rumor that "after September, buyers who have been divorced for less than one year will be treated according to their family situation before divorce." As a result, families who were afraid that they could not buy a house after the New Deal began to queue up for divorce. Although, it was later proved that this was a rumor fabricated by a real estate salesman. However, divorce to buy a house has always existed. Marriage is to protect the family, but now it has become a tool for profit-seeking. Is this the irony of the marriage system or a silent accusation against the real estate system?

Real estate in first-and second-tier cities is out of control, and many cities have introduced purchase restriction policies.

In September this year, the property market went crazy again. Nanjing sold 1,500 sets of houses, and Hefei property buyers rushed for houses in the rain. The price of a building more than 20 kilometers away from the main city of Hangzhou jumped directly from 6,000 yuan to 9,500-11,500 yuan. In Shenzhen, a 6-square-meter pigeon cage with a price of 150,000 yuan per square meter broke out, and the people of the whole country were like witchcraft.

With the booming property market, the purchase restriction policy was immediately introduced. Around the National Day Golden Week, the purchase restriction orders of nearly 20 cities were intensively introduced, and the real estate market in many places was sorrowful. The turnover of new houses in hot cities such as Beijing, Hangzhou and Nanjing declined in a cliff-like manner. At the same time, due to the influence of the New Deal and the adjustment of the down payment ratio, many property buyers have to cancel their contracts because they can’t afford to buy a house.

On the other hand, due to the property market restriction, some funds began to switch to A shares or overseas insurance, which objectively created the structural market of A shares after the National Day and the enthusiasm of mainland investors for Hong Kong insurance.

China CDSWill the real estate bubble be good when it strikes?

On September 23rd, China Association of Inter-bank Market Dealers "Business Rules for Pilot Credit Risk Mitigation Tools in Inter-bank Market" (hereinafter referred to as business rules) and related supporting documents, based on the original two products, launched two new products, including credit default swaps (CDS).

In the movie "Big Short", the protagonist from Wall Street saw the bubble of real estate subprime loans and made huge profits by shorting CDS. Therefore, CDS is also considered to be an important driver of the 2008 financial crisis.

Whether the China version of CDS can help squeeze out the real estate bubble remains to be seen.

Li Ka-shing sells mainland property and withdraws from China.

In October this year, Changjiang Industrial Real Estate Co., Ltd., a subsidiary of Li Ka-shing, announced that it would sell the "Century Hui" complex in Lujiazui, Shanghai for 20 billion yuan. This transaction will bring Cheung Kong Real Estate 5.43 billion yuan, which is also the largest property sold in mainland China by Li Ka-shing so far.

At the same time, Li Ka-shing focused its investment on Europe — — Britain, in particular, has invested in power, natural gas, transportation, retail and other fields, and focused on infrastructure. Britain has become Li Ka-shing’s biggest profit source.

The main reason for Li Ka-shing’s selling of mainland real estate is that there are too many bubbles in mainland real estate, and the risks outweigh the opportunities. Early action can make the company in an invincible position.

The Central Economic Work Conference decided that "the house is for living, not for speculation"

In December, the Central Economic Work Conference was held in Beijing, which mentioned that "houses are used for living, not for speculation", which not only curbed the real estate bubble, but also prevented ups and downs; Cities with high pressure of rising housing prices should reasonably increase land supply, and megacities should speed up the relief of some urban functions and promote the development of surrounding small and medium-sized cities; It is necessary to speed up the legislation of the housing leasing market and accelerate the development of institutionalized and large-scale leasing enterprises.

According to the content of real estate in the meeting, it can be inferred that the era of getting rich by real estate speculation has passed and real estate will return to the residential property; The functions of first-tier cities such as Shanghai and Shenzhen will be evacuated, and there will be more opportunities in surrounding small cities; The focus of the real estate industry will gradually shift from the buying and selling market to the leasing market, which may be the next opportunity for the real estate industry.

Author: Zhao Xiaotao 1 Cong Yulong 2

SETTING: 1. Clinical Laboratory of Peking University People’s Hospital, 2. Clinical Laboratory Center of PLA General Hospital.

Zhao Xiaotao

Deputy Director, Laboratory Department, Peking University People’s Hospital

Chief physician/professor, master tutor. Engaged in clinical molecular detection and related basic research. As the project leader, he was supported by the National Natural Science Foundation of China and the Beijing Natural Science Foundation, and published many core journals and articles in SCI as the first or correspondent author. Major social workers are members (and secretaries) of the Department of Medical Laboratory in peking university health science center; Standing Committee member (and Secretary-General) of Clinical Microbiology and Infection Branch of China Health Care International Exchange Promotion Association; Deputy head of the special working group on scientific research and postgraduate training of Beijing Inspection Society of Chinese Medical Association; Member of Molecular Diagnosis Group of Laboratory Medicine Branch of Chinese Medical Association; Director of Laboratory Specialist Branch of Beijing Medical Doctor Association; Member of the Special Committee of Laboratory Medicine of China Association of Integrated Traditional Chinese and Western Medicine; Standing Committee of Laboratory Medicine Committee of Beijing Society of Integrated Traditional Chinese and Western Medicine; Member of Laboratory Medicine Branch of China Medical Equipment Association; Member of China Medical and Health Care International Exchange Promotion Association, grassroots inspection technology standardization branch, etc.

Malignant tumor is an important disease endangering human life and health, and its incidence has long been at the forefront of disease spectrum and death spectrum, which is a disease of universal concern. The online cloud live broadcast mode was launched for the first time in the 26th National Cancer Prevention Publicity Week held from April 15th to 21st, 2020, and 21.456 million people watched the live broadcast nationwide. This shows that the national medical and health field and the whole society pay attention to the prevention and treatment of malignant tumors. At present, the burden of malignant tumor is still rising in China, which seriously affects people’s health and social life. In recent 10 years, the incidence of malignant tumors in China has increased by about 3.9% every year, and the mortality rate has increased by 2.5% every year. According to the data released by the National Cancer Center in 2019, there were about 3.929 million cases of malignant tumors and 2.338 million deaths in China in 2015. The top five cancers in China are lung cancer, gastric cancer, colorectal cancer, liver cancer and breast cancer, among which lung cancer and breast cancer rank first among men and women in China respectively. At present, the five-year survival rate of cancer patients in China is about 40%, which is 10% higher than that of ten years ago, but there is still a certain gap compared with developed countries. The reason is that early diagnosis, early treatment and precise medical treatment are the key to prevent and cure tumors, and one of its important means is the extensive and effective application of molecular biological diagnosis technology in clinical laboratories.

1. The development of medical molecular biology promotes the wide application of molecular diagnosis technology in precision medicine.　

Medical molecular biology refers to the study of the structure and function of biological macromolecules at the molecular level, so as to clarify the nature of life phenomena. In recent years, with the emergence of new technologies in the field of medical molecular biology and the continuous improvement of bioinformatics data, the level of molecular diagnosis in clinical laboratories has been greatly promoted, and the progress of medical science has been promoted, so that the diagnosis and treatment of diseases in clinical medicine has risen to a brand-new realm, from morphological or cellular level to the explanation of the mechanism and accurate diagnosis and treatment of malignant tumor diseases from gene level and molecular level, so as to achieve early diagnosis and even susceptibility assessment of diseases, and to evaluate the stages, types, treatment effects and prognosis of diseases. Molecular biology has become an important development direction of modern medicine and precision medicine.

In the field of clinical medicine, the application scope of molecular biology technology and methods is expanding day by day, and its research content and technical means are deepening. At present, it has penetrated into all fields of medicine, including molecular detection of pathogenic microorganisms, genetic detection and diagnosis of congenital diseases and hereditary diseases, genetic detection and diagnosis of malignant tumors, as well as individual drug use gene detection that affects drug metabolism, drug resistance and toxic side effects, individual identification, gene detection related to transplant matching, non-invasive prenatal detection (NIPT) and embryo implantation. Among them, gene detection related to targeted therapy of malignant tumor, multi-locus tumor-related gene detection related to heredity, susceptibility, treatment and prognosis, and whole exon gene detection play an important role in accurate diagnosis, prevention and treatment of malignant tumor.

Second, tumor molecular diagnostic markers and new detection technologies provide an important basis for clinical risk assessment of malignant tumors.

In clinical research, it is the direction of clinical medicine, especially clinical tumor research and basic research, to continuously discover new diagnostic markers of malignant tumors and further explore and study the pathological mechanism of malignant tumors. From the discovery of Bence-Jones protein in the urine of patients with multiple myeloma by Henry Bence-Jones in 1846, which was used as the first tumor marker for the diagnosis of multiple myeloma, up to now, more than 100 tumor markers have been discovered, including protein tumor markers, sugar tumor markers and enzyme tumor markers. With the development of molecular biotechnology, there are more and more categories of tumor biomarkers, such as specific gene mutation, which can affect the effect of tumor-targeted drug therapy, genes related to cell growth and differentiation, oncogenes, tumor suppressor genes and their products that play a key role in the occurrence and development of tumors, and single nucleotide polymorphism, genome, transcriptome and proteome can all be used as tumor biomarkers. From tumor-related chromosomal abnormalities to tumor-related genetic abnormalities, from tumor-related single nucleotide polymorphisms to tumor-related epigenetic abnormalities, and the study of new molecular markers such as miRNA and LncRNA provide powerful tools for accurate diagnosis and treatment of malignant tumors in clinic. By detecting these molecular markers, we can assess the risk of cancer and make early diagnosis, monitoring, early warning, intervention,Reduce the risk of cancer and improve the treatment effect, slow down the development of cancer and even prevent the intervention of cancer.

Due to the rapid development of molecular biology technology, the detection of molecular markers of malignant tumors is more and more accurate and efficient. From the discovery of nuclein by F.Miescher in 1868 to the discovery of double helix structure of deoxyribonucleic acid (DNA) by Watson and Crick in 1953, from the invention of polymerase chain reaction (PCR) by Mullis in 1985 to the wide application of NGS NGS((Next-generation sequencing, also known as second-generation sequencing) technology developed in recent years, from the technical means, At present, the Amplified Arrested Mutation System (AMRs) is applied in clinic, which can be used to detect low-frequency mutations and detect 1% mutations in tissues and cells. More sensitive digital PCR technology can detect 0.1% mutation. For the traditional Sanger sequencing, although it is less sensitive, it has advantages in detecting germline mutations, high-frequency mutations, unknown mutations, clear target genes and few genes. NGS technology has the advantage of Qualcomm, which can sequence hundreds of genes, whole exons and whole genomes at one time. With the maturity of technology, more standardized management, continuous improvement and updating of biological information database, and perfection of data interpretation, combined with technologies such as detecting tumor cells in peripheral blood and free nucleic acids in peripheral blood, through overcoming the heterogeneity of malignant tumors,It will greatly promote the development of this technology and have a broader clinical application prospect.

Third, with the diagnosis of cancer patients tailored to provide the best solution for accurate diagnosis and treatment of malignant tumors.

At present, with the continuous development of molecular biology technology and the popularization of molecular diagnosis technology in clinical laboratories, the clinical oncology is increasingly widely used in individualized medicine, precision medicine and targeted therapy. Therefore, the concept of companion diagnostics (CDx) came into being. Adjoint diagnosis is an in vitro diagnostic technique related to special drugs, which can identify the best drug users by detecting the variation of proteins and genes in human body and the expression level of genes. The application of CDx in patients with malignant tumor can not only screen out effective treatment schemes for patients, save the time and cost of ineffective treatment, but also improve the compliance of patients taking drugs and reduce unnecessary toxic and side effects.

The development of accompanying diagnosis shows that the correlation between the expression of estrogen receptor and the efficacy of endocrine therapy in breast cancer patients has been studied since 1970s, from protein level to molecular gene level. Herceptin, the first adjoint diagnostic reagent approved by FDA in September, 1998, was used to detect people who used anticancer drug Herceptin, a humanized monoclonal antibody targeting the extracellular structural region of HER-2 receptor tyrosine kinase. As the driving gene of non-small cell lung cancer, epidermal growth factor receptor (EGFR) has a sensitive mutation rate of 30%~40% in Asian population. TKI (tyrosine kinase inhibitor) is used as a targeted therapy for such non-small cell lung cancer patients, and their survival time is significantly prolonged, and their tolerance and quality of life are higher than those of traditional chemotherapy. Up to now, FDA has approved NGS associated diagnosis and detection products with multiple genes and cancers, covering 324 genes, including microsatellite instability (MSI) and tumor mutation load (TMB). At present, most of the applications of adjoint diagnosis are used in tumors, mainly including clinical management of non-small cell lung cancer, melanoma, breast cancer, colorectal cancer and ovarian cancer. Adjoint diagnosis plays an indispensable role in precision medicine, and its application scope is gradually expanding. It is predicted that it will be developed in the fields of pharmacogenomics, autoimmune diseases, cardiovascular diseases, central nervous system, infection and so on.

Four, clinical laboratory molecular diagnosis quality assurance and technical specifications and market supervision has a long way to go.

The market demand and development potential of cancer medical treatment promote the development and application of In Vitro Diagnosis (IVD) instruments and reagents, and new technologies emerge one after another. On the other hand, institutions for tumor genetic testing have also flourished. The results of tumor detection are related to the diagnosis, treatment and prognosis of the disease, which can be said to be related to the existence of a life. However, due to the high sensitivity and diversity of molecular detection technology, as well as the complexity and uncertainty of specimens and experimental operations, the quality assurance of tumor-related molecular detection is particularly important. From the research and development of reagents and equipment, to the determination of expected clinical use, the establishment and optimization of methods, from the range control of indications to the selection of detection items, methods adopted, the performance confirmation of LDTs or the performance verification of kits, from the selection of specimen types to the collection and transportation of specimens, from the design and layout of space environment to the qualification of personnel, equipment, reagents and technical specifications, from bioinformatics analysis to the interpretation of genetic variation in tumor molecular detection reports, and so on. In order to standardize the medical behavior in the field of tumor genetic testing, the health administrative department has successively issued a number of rules and regulations, and clinical and laboratory experts have also actively formulated national or industry standards, written relevant guidelines, expert consensus, etc., coordinated supervision and liberalization, and jointly promoted the orderly and healthy development of the field of tumor molecular testing.Effectively serve the accurate diagnosis and treatment of clinical malignant tumors.　

With the completion of the human genome project and the post-genome era, as well as the completion of genome-wide association study () of all malignant tumors, more new molecular targets of malignant tumors will be continuously discovered and applied to clinical diagnosis and treatment. At the same time, with the continuous introduction of the application management policy of molecular diagnostic technology and the improvement of supervision, many genetic tests related to malignant tumors will gradually move from basic scientific research to clinical application. The joint application of various molecular biological detection technology platforms, the in-depth study of various new targets, and the intersection and penetration with other disciplines make molecular biological detection play an increasingly important role in the diagnosis, prevention, treatment, drug research and development of malignant tumors. Molecular detection technology in clinical laboratories will help promote the accurate detection, accurate diagnosis, accurate treatment, accurate prediction and accurate prevention of malignant tumors, so that it can serve human health more efficiently and push medical science forward continuously.

Note:This article comes from the topic "Tumor and Adjoint Diagnosis" in the 5th issue of Clinical Laboratory in 2020.

　
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Title map | veer.com 　
Original release date | May 8, 2020　 　

Clinical Laboratory is a journal of medical laboratory technology, with 12 issues a year, each with different topics, tracking industry hotspots, capturing industry direction and paying attention to development frontiers. The electronic version is updated in real time every month, and colleagues are welcome to follow up.

[Click to watch the exclusive video]

　"The Song of the Movie" entered Tongxiang, Jiaxing, and Elva Hsiao featured "Strangers"
　"The Song of the Movie" entered Wen Lan, Tongxiang, Jiaxing, and the opening ceremony set off a boom.　
　"Movie Song" Walks into the Rain of Wang Feng, Tongxiang, Jiaxing and "Fly Higher"

　　Movie network news(Photo/Zhang Hangyuwen/Fifth Tiefeng) On the evening of October 23, the concert "Song of the Movie" was passionately staged in the autumn rain in Tongxiang, Zhejiang. Although the whole concert was held in the rain, the enthusiasm of the audience and the actors on the stage did not diminish at all. The wonderful performances of Chen Chusheng, Wu Kequn, Elva Hsiao and Alan Tam not only made the fans forget the cold rainy night, but also made the atmosphere of the whole concert warm and abnormal. In addition, Wen Lan, An Youqi, Wang Zhengliang, Tong Ange, Li Guyi and Priscilla Chan also won a lot of applause and screams from the audience.

Wu Kequn triggered the first wave of climax, and Chen Chusheng sang deeply and was very popular.

　　Wu Kequn’s first song was "your legend", and at this time, when the rain was the heaviest, Wu Kequn sang and danced in the heavy rain, which also triggered the first wave of climax of the audience, and the female fans at the scene screamed again and again. In the second song "Love is Power", Wu Kequn’s affectionate interpretation hit every audience present. Enthusiastic fans rushed to the stage to shake hands with Wu Kequn regardless of the heavy rain and the on-site security guards, and gave their light sticks to idols. "Today’s rain is really heavy, and I see that you are all wet, so the following song is related to wet (poetry)," Writing Poetry for You ",as one of Wu Kequn’s most famous masterpieces, fans sang this song with Wu Kequn while waving light sticks.

　　The appearance of another popular singer, Chen Chusheng, triggered the second climax of the audience. "Forgetting in Jianghu" is the theme song of the film being shown. In the drizzle, dancers draw their swords and dance, and an altar of good wine can’t be filled with heroic pride. Chen Chusheng’s affectionate singing shows how many Jianghu children forget in Jianghu. Hawthorn Flower sings another beautiful love story. The last song "Did Someone Tell You" is destined to be a chorus. For Chen Chusheng’s loyal fans, this song touched countless fans on the talent show stage in 2007, and every note represents the best memories of that summer.

Elva Hsiao Hot Dance Explodes Passion Alan Tam Encounters Male Fan Bear Hug

　　As the divas of the whole concert, Elva Hsiao and Alan Tam proved their strength and status with the highest popularity and screams. Elva Hsiao’s dynamic new song "Miss Handsome" with the dance in the rain immediately ignited the enthusiasm of the audience. Elva Hsiao fans sitting in the front row area flocked to the edge of the stage to interact with Elva Hsiao on the stage regardless of the pouring rain. Subsequently, Elva Hsiao’s classic old song "The Most Familiar Stranger" aroused another affectionate chorus in the audience, and both the loyal fans of Elva Hsiao and the general audience sang along with the beat of the music. After Qu Bi, Elva Hsiao said in an interview with the host Hantao Wang that although it was raining heavily, she was moved by the fans in the audience. "I still remember that the first ticketing concert since my debut was held in heavy rain, and a place in Central Taiwan Province was experiencing typhoon weather." Elva Hsiao took another fast song, and "Confession" sang what she wanted to say most to the audience and what she wanted to express her gratitude and gratitude.

　　The final climax of the audience came from Alan Tam, who was "25 years old forever". A song "Kara is OK forever" made the older audience stand up and sing in chorus. Alan Tam joked, "I thought everyone had left." The audience at the scene shouted: "Principal, we are here." As an evergreen tree in the music world, Alan Tam’s charm can be said to be unmatched, so that when the second song "Friends" was played, the audience stood up and sang in chorus, which became the climax of the whole concert. An emotional male fan even suddenly climbed onto the stage and gave Alan Tam a "bear hug" from behind, which made Alan Tam dumbfounded. When a song "Love in Late Autumn" was deeply sung by Alan Tam, the whole concert came to the warmest end, and the audience waved their light sticks and sang along gently as they left.

Wang Feng sang in front of the audience in Yao Di’s hometown in the rain.

　　"Life in Full Bloom" made Wang Feng burn the audience’s enthusiasm in the rainy night in the south of the Yangtze River. Then a new song "In Spring", Wang Feng’s dull voice sang the longing for life. "The next song is an old song. I have been singing it for many years, but this time I hope to hear it from your heart." Wang Feng ended his passionate performance with a highly sung "Fly Higher", and the audience completely threw the cold out of the clouds with their hard screams.

　　Wuzhen, a water town in the south of the Yangtze River, has attracted countless tourists, and at the same time, it has become the shooting scene of many film and television dramas. There are many scenes in the new version that has just attracted great attention nationwide. Yao Di, the young actor who plays Wang Xifeng in the play, happens to be a native of Tongxiang. This time, in order to meet the folks in his hometown, Yao Di even pushed off a lot of work at hand. "My work schedule was very full these days, but when the concert of" Song of the Movie "found my agent, I said that I must come back to Tongxiang to meet you anyway." A song "Dream of the Red Mansion" won warm applause from the audience.

The actor of "Song of the Movie" guest sang "Borrowed Starlight" on vcr.

　　Although the host of the whole concert was Hantao Wang, the famous host of Michelle’s partner movie channel, there was actually another group of "off-site hosts". They were the four leading actors of the multimedia musical Song of the Movie, Ning, Liu Lu, Liu Yang and Liu Jiuzhang. They shared the simple and elegant natural and cultural scenery of Wuzhen with the audience by recording VCRs, and also introduced the special product "Hangbaiju" of Tongxiang. The four leading actors performed wonderfully in the new musical Song of the Movie, and they just returned from a world tour in Taiwan Province. They sang a song of Song of the Movie, Borrowed Starlight, on the spot, so that the audience who didn’t see the musical Song of the Movie could appreciate the charm of the musical through this short performance.

Related information:Elva Hsiao’s hair was soaked and her head was wrapped in a towel. Wen Lan only wore a vest, and the heat was not reduced

Reading tips

From science to science fiction, and then from science fiction to science, this collision between literary and artistic works and science and technology has created countless surprises. The national team of scientists escorted the domestic sci-fi movies to the world and sounded their horns. In this process, they also spread the seeds of science to a larger audience. This is a great attempt for China’s film and television industry and popular science.

　

"Does cosmic flicker really exist?" "Is digital life feasible?" "If a day becomes 60 hours, how many hours do we have to work?" … …

The audience who are still immersed in the domestic sci-fi movies such as Wandering Earth 2 and TV series Three-body, after two brushes and three brushes, are continuously shocked by the grand and complete world view shown in the film and begin to stare at the starry sky overhead. They gave many questions about astronomy, physics, artificial intelligence, chemical materials and other disciplines to the scientific advisers of the two works.

With the same expectations as the audience, Workers Daily interviewed four scientists from China Academy of Sciences who tailored the world outlook for domestic science fiction: Gou Lijun, a researcher at the National Astronomical Observatory, Wei Hongxiang and Liang Wenjie, a researcher at the Institute of Physics, and Wang Yuanzhuo, a researcher at the Institute of Computing Technology.

From formula to screen

The reason why Wandering Earth 2 and Three-body are defined as milestones of domestic science fiction is that they have a huge and complete world outlook (the general views and opinions of the film on the whole world and the relationship between people and the world).

Whether it is the big ideas of "exploding the moon", "digital life", "space elevator" and "guzheng action", or the dense formulas that exist as background boards in Wei Cheng’s room on the wall of Tu Hengyu, they are supported by scientific consultants.

It is understood that "Wandering Earth 2" hired 19 experts from various fields to form a scientific advisory group, which made detailed settings for the world view of the film. The whole script is 70,000 words, but the world view behind it is over 200,000 words. During the seven-year preparation and shooting of the drama "Three-body", 60 or 70 scientific consultants have joined it.

As a fresh force of domestic science fiction, "scientific consultant" is the first time for the film and television industry and the first time for the group of scientists. They not only created a new world in their works, but also created a new pattern of domestic science fiction industry.

Wang Yuanzhuo contributed the plot line of "People in the Loop" to Wandering Earth 2. "We can’t demand that the scientific knowledge in science fiction movies is 100% accurate, which is a big premise." In his view, science and artistry need to find a balance point, so that the audience can be brought into the plot with "realism" and enjoy the beautiful impression brought by the wide opening of their brains.

"The setting of scientific knowledge that we know and have reached consensus, such as artificial intelligence, digital life and brain-computer interface, should be more professional. At the same time, it is reasonable to have a false desire for the future, at least at a set point in time. "

Under his design, the 550 series intelligent quantum computers in the film are very small and can even be taken to the moon with them, but they are extremely powerful and iterative. Its appearance and development also give the film a realistic basis for discussing digital life. This kind of imagination is not illusory, because from the current situation of the development of quantum computers and artificial intelligence, the audience can accept and understand without obstacles, and even think and explore further.

The most unforgettable thing for Liang Wenjie is the setting of the plot of bombing the moon. The original design of the script was to assemble all the nuclear bombs on the earth to blow up the moon, but the astrophysics group found that this was not feasible after calculation. But this plot must exist, so scientists began to collectively "burn their brains". After several rounds of discussions between the Astrophysics Group and the Theoretical Physics Group, the scheme of "phased array nuclear explosion on the moon" was formed, which perfectly balanced science, vision and plot.

The channel of branch and shadow fusion has been opened.

Liang Wenjie is the scientific consultant of Wandering Earth 2 and the drama version of Three-body. At the beginning, he had some doubts about being a scientific consultant. "If I just invited scientists to endorse it, I wouldn’t agree."

After these cooperations, he now has a sense of trust in the increasingly mature industrialization of domestic science fiction films. "The production team is very serious about the construction of the world outlook. Sometimes scientists think it is ok, but the production team is still constantly improving, and the final visual effect is also very shocking."

Wandering Earth 1, released in 2019, opened the door to domestic sci-fi movies, and also brought opportunities for integration between the film and television industry and the scientific community. In 2020, the National Film Bureau and the China Association for Science and Technology issued the "Several Opinions on Promoting the Development of Science Fiction Films" called "Ten Science Fiction Articles"; Subsequently, the National Film Administration and the China Association for Science and Technology took the lead in establishing a science advisory library for science fiction films, and hired a group of academicians of the two academies, authoritative experts and outstanding scientific and technological workers as experts in the scientific advisory library. At the end of 2020, the Chinese Popular Science Writers Association established a professional committee for the integration of science and film and television.

The four scientists interviewed by Workers Daily have interacted with sci-fi movies for a long time.

When Wandering Earth 1 was released, Wang Yuanzhuo drew a scientific explanation map by hand in order to popularize the knowledge points in the film for his daughter. In order to preserve it better, he posted it in his Weibo, but he didn’t expect to get 150 million readings.

Gou Lijun came into contact with the concept of "scientific consultant" earlier. In 2014, Interstellar was released. As a researcher, he was greatly shocked and excited by the sci-fi worldview with black holes, wormholes and gravitational waves as clues. Kip Thorne, a scientific consultant and physicist who learned about the film, also wrote a popular science book with the same name to introduce the scientific story behind the film. Gou Lijun wrote an email to the later Nobel Prize winner overnight, eager to translate the book. Finally, the professional fan’s wish came true. Gou Lijun, who is in his 40 s, talks about this experience and still has stars in his eyes.

"Before the release of Wandering Earth 1, I went to see the film. At that time, there was no post-production. Many scenes we saw were still green scenes, which could only be explained by director Frant Gwo ‘Brain tonic’ . Even so, everyone is very excited, because we finally saw the start of domestic science fiction. "Gou Lijun recalled.

In addition to the deep participation of scientists, the scientific community also supports domestic sci-fi films, and even approved the crew to enter the particle collision center and the National Nanoscience Center for live shooting for the first time.

Reaction of science fiction works

In bilibili, where young people gather, the "Second Institute of Physics of Chinese Academy of Sciences" has a huge number of fans. Wei Hongxiang, as the main contributor, believes that it is because he has found a way to communicate with young people.

"More than half of the fans are high school students." Wei Hongxiang has been doing popular science for teenagers for more than ten years. Recently, he found that more and more teenagers expressed their ideal of becoming scientists.

In his view, science, popular science and science fiction have a mutually reinforcing relationship. Popular science is to let everyone understand scientific concepts and principles. Science fiction, on the other hand, makes more people think about bigger and more future problems. It strives for more people’s recognition and understanding for some major events related to the future of mankind, and unites more people to work together to solve and overcome them.

"Science fiction works can bring people a kind of inner strength. When you have no confidence in yourself or are confused about the future, he will guide you to think and act." Wei Hongxiang said.

"Our scientific planning in reality is usually three or five years, and we rarely look at today’s work from the perspective of the next few decades. When we look at the current research from the perspective of science fiction, there will be many new ideas. " Wang Yuanzhuo said.

Gou Lijun recalled that the most important thing for him to become a "stargazer" was to read the science fiction magazine UFO Exploration in his youth. Today, what scientists want to do is to make more people love and yearn for science with the help of science fiction fever.

"Science fiction movies are an important way for popular science and scientific research to face more people. At the same time, through the presentation of sci-fi literary works, the direction of research and exploration in the scientific field will be paid more attention to by more people, which is also very important for scientific research itself. " Liang Wenjie said.

　　China Net Finance March 4 (Reporter Hu Aishan) On the evening of February 29 on the eve of the two sessions, the central bank announced the RRR cut — — Since March 1, the RMB deposit reserve ratio of financial institutions has been lowered by 0.5 percentage point to maintain a reasonable and sufficient liquidity in the financial system, guide the steady and moderate growth of money and credit, and create a suitable monetary and financial environment for supply-side structural reform. This is the first RRR cut by the central bank this year.

　　2016 is the first year of the decisive stage of building a well-off society in an all-round way in China. The CPC Central Committee with the Supreme Leader as the general secretary holds high the banner of deepening reform, is brave in practice and is good at innovation, and points out the direction for the future economic development of China.

　　The financial industry plays an important role in economic development. The key areas of China’s economic construction, major projects and weak links such as small and micro, "agriculture, countryside and farmers" are all inseparable from the financial support.

　　On July 17, 2015, General Secretary of the Supreme Leader held a symposium of leading comrades of some provincial party committees in Changchun, pointing out: "It is necessary to improve financial services and dredge the channels for finance to enter the real economy, especially small and medium-sized enterprises and small and micro enterprises."

　　The speech of the Supreme Leader General Secretary pointed out the problems existing in the process of China’s financial development — — It is in the past that small and medium-sized enterprises faced the problem of financing difficulty and expensive financing in the development process. This "short board" has seriously restricted the healthy development of China’s economy.

　　It has been seven years since the outbreak of the international financial crisis, and the recovery of the world economy is still slow and the growth is still fragile. The important reason for the international financial crisis was that financial development gradually separated from the real economy. On September 5, 2013, General Secretary of the Supreme Leader pointed out at the G20 Summit that "we should continue to strengthen the supervision of the international financial market so that the financial system can truly rely on, serve and promote the development of the real economy."

　　The above speech by the Supreme Leader General Secretary pointed out the development direction of the financial system. Whether it is the world financial system or China financial system, it should be attached to the real economy, serve the real economy and promote its development.

　　To this end, the Central Economic Work Conference held at the end of last year pointed out that in order to reduce the financial costs of enterprises, the financial sector should create a policy environment of interest rate normalization and make profits for the real economy.

　　In the past 2015, China’s banking system has achieved remarkable results in serving the real economy, keeping the bottom line of risks and deepening reform and opening up.

　　In 2015, China added 11.2 trillion yuan of credit funds, 8.5 trillion yuan of wealth management funds, 6.1 trillion yuan of bond investment and 2.3 trillion yuan of trust funds, and revitalized more than 1 trillion yuan of existing loans through asset securitization and disposal of non-performing loans. The newly added and revitalized existing funds are mainly used to support key areas, major projects, small and micro, "agriculture, rural areas and farmers" and other weak links.

　　Last year, the China Banking Regulatory Commission formulated the development plan for inclusive finance, improved the overall policy framework for inclusive finance’s development, strengthened supporting policies for financial services in weak areas, and achieved the goal of "three no less than" loans for small and micro enterprises. By reducing fees and profits to reduce the cost of social financing, the fees charged by 21 national banks have been greatly reduced.

　　At the end of last year, the State Council issued the Plan for Promoting the Development of inclusive finance (2016-2020), which established the implementation strategy of inclusive finance at the national level for the first time. The plan points out that vigorously developing inclusive finance is an inevitable requirement for China to build a well-off society in an all-round way, which is conducive to promoting the sustainable and balanced development of the financial industry, promoting mass entrepreneurship and innovation, and boosting the transformation and upgrading of the economic development mode.

　　To this end, the China Banking Regulatory Commission proposed to further promote the reform and opening up of the banking industry in 2016. The concrete manifestations are: realizing the normalization of the establishment of private banks and expanding the channels and ways for private capital to enter the banking industry. Support private capital to participate in the restructuring of city commercial banks and rural small and medium-sized financial institutions. Support qualified private capital to initiate the establishment of consumer finance companies, financial leasing companies, enterprise group finance companies, auto finance companies and participate in the establishment of village banks.

　　In order to make the real economy enjoy lower financing costs, the central bank has implemented some monetary policies. According to the working paper "Macroeconomic Forecast of China in 2016" recently released by the central bank, since November 22, 2014, the central bank has cut interest rates and lowered the benchmark interest rate for one-year time deposits from 3.0% to 1.5%, and the benchmark interest rate for medium and long-term loans from 1 to 3 years from 6.15% to 4.75%.

　　Due to the adjustment of these policies and some directional control measures (including refinancing, targeted cuts to required reserve ratios, etc.), the risk-free interest rate and the financing cost of enterprises have dropped significantly. In addition, private lending rates and P2P lending rates also showed a downward trend.

　　On October 29, 2015, General Secretary of the Supreme Leader pointed out at the second plenary session of the Fifth Plenary Session of the 18th CPC Central Committee that "enterprises should make profits. The reason why an enterprise is called an enterprise is that it must make profits. Enterprises have no profits and large-scale losses, and they can’t survive after two or three years. That is not only a problem of slower speed, but also the income of employees and government finances, and it will bring financial risks and even social risks. Our policy base should be placed on enterprises, especially real economy enterprises, attach great importance to the healthy development of the real economy and enhance the profitability of the real economy. "

[car home Zhaotong Preferential Promotion Channel] Recently, people in Zhaotong area are enjoying generous discounts, with a maximum discount of 110,000 yuan. The lowest starting price is only 359,900, and the preferential margin is gratifying. If you are interested in BMW i4, you may wish to click "Check the car price" in the quotation form to get a higher discount.

BMW i4 adopts a fashionable and futuristic design. In the front part, the unique kidney-shaped air intake grille has been redesigned to present a closed structure to adapt to the characteristics of electric vehicles. The grille and LED headlights are integrated to create a highly recognizable visual effect. On the whole, the design concept of BMW i4 is dynamic and elegant, and the body lines are smooth and powerful, showing a modern sports style.

The body size of BMW i4 is 4785*1852*1455mm, the wheelbase is 2856mm, and the front and rear tracks are 1601mm and 1630mm respectively. The side lines of the car body are smooth and dynamic, showing a strong sporty atmosphere. Equipped with 18-inch wheels, with 245/45 R18 front tires and 255/45 R18 rear tires, the handling performance and stability of the vehicle are further improved.

The interior design of BMW i4 not only embodies the sense of luxury but also does not lose the sense of technology. The center console is equipped with a 14.9-inch display screen, which integrates the functions of multimedia system, navigation, telephone and air conditioning, and supports voice recognition control. The steering wheel is made of leather, which can be manually adjusted up and down and front and rear positions to provide a comfortable driving experience. A number of USB and Type-C interfaces are provided in the car, which is convenient for passengers to charge electronic equipment, and it is also equipped with wireless charging function of the front mobile phone. The seats are made of various materials, including imitation leather, genuine leather and leather /Alcantara mix-and-match. The main and co-pilot seats have heating function, and support many adjustments, such as front and rear adjustment, backrest adjustment, height adjustment, leg rest adjustment and lumbar support adjustment, which improves the comfort of drivers and passengers. In addition, the driver’s seat is also equipped with electric seat memory function, which is convenient for the driver to quickly adjust to the appropriate sitting position. The rear seats can be laid down in proportion to increase the flexibility of luggage space.

The BMW i4 is equipped with a powerful motor with a maximum power of 210kW and a maximum torque of 400 Nm. This provides excellent power output and a smooth driving experience.

Car home car owners highly praised BMW i4, especially its sound insulation effect, abundant power and unique design. He mentioned: "I don’t think I will lose my sister Mercedes-Benz if the volcanic red interior is made." This evaluation not only reflects the excellent quality of BMW i4, but also shows its care in details.

Hebei News Network (Chen Xi) Auto Market News Express lets you know the latest trends in the automotive industry and brings you the most immediate new car information. The main information in this issue is: Geely brand will release new energy strategy this month, medium and large pure electric car new volume king, Feifan F7 stunning debut, Chery Tiggo 9 latest official picture exposure… Let’s pay attention together!

First, the latest news in the industry

Geely will release its new energy strategy on February 23

On February 4, 2023, Gan Jiayue, CEO of Geely Automobile Group, announced at the internal annual business work conference that the Geely brand will officially release the "Geely Brand New Energy Strategy" at the main venue of the Hangzhou Asian Games on February 23, and launch the Geely brand mid-to-high-end new energy series. The first smart electric product of this series will also usher in the world debut.

Last year, Geely Automobile New Energy ushered in explosive growth, with the penetration rate tripling year-on-year and exceeding 30% in a few months. This year is the year of acceleration of Geely’s transition to smart new energy. Geely brand mid-to-high-end new energy series will launch a number of new products including large-mileage PHEVs and smart pure electricity within three years.

Geely has always adhered to the true nature of "car builder" and insisted on "long-term doctrine" to win. In the intelligent new energy track, Geely is led by the new energy intelligent architecture and Raytheon intelligent electric hybrid technology, and continues to empower the "new infrastructure" of heaven and earth integration such as intelligent computing center and low-orbit satellites, and is committed to creating a new ecosystem of intelligent travel.

Second, the new car is on the market

The new volume king of medium and large pure electric cars, Feifan F7 stunning debut, 280,000 yuan starts pre-sale today

Recently, Feifan F7, the first medium and large pure electric flagship sedan of Feifan Automobile, made a stunning appearance at Shanghai’s trendy landmark TX Huaihai and officially opened the reservation. The pre-sale price is 28-350,000 yuan.

As a concept model of the Red Dot Design Award, Feifan F7 is stunning in shape and exceeds users’ expectations with intelligent technology. The new car is 5 meters long and has a wheelbase of 3 meters; it is equipped with a RISING MAX 3 + 1 technology entertainment cabin, equipped with the industry’s first two-way dual-zone independent cinema scene and scene-based 3D vector MegaBass; it follows the European luxury car tuning concept to create a unified dynamic experience for driving; it is equipped with high-standard lidar, ZF Premium 4D imaging radar, NVIDIA Orin chip and other top-level smart driving hardware and RISING PILOT fully integrated high-end smart driving system; as well as 666km CLTC super long battery life and "rechargeable, exchangeable and upgradable" power exchange architecture, becoming the "new luxury smart seat" in the era of smart trams.

The smooth body lines not only bring excellent visual enjoyment, but also lay the foundation for its drag coefficient as low as 0.206Cd, setting a record for the lowest drag of its own brand production cars certified by China Automotive Research Institute in one fell swoop. At the same time, Feifan also launched an exclusive "raw coconut latte" body color for F7, and has exclusive wheels of the same color for the body.

Adhering to the aesthetic design of luxury supercar potential energy, Feifan F7 fully considers practicality and experience. The 1.98m ² large Xingyao dome canopy, with the front and rear triangular window design, makes users feel like they are in a moving sun room. At the same time, the Xingyao dome canopy also adopts a double-layer sound insulation design, which is not afraid of high temperature and ultraviolet rays in summer, and prevents temperature loss in winter to ensure warmth in the car.

In addition to the pleasing appearance, excellent performance and driving control are also important criteria for testing the sense of luxury. Feifan F7 has a maximum power of 400kW, 700Nm peak torque, and only 3.7s for zero hundred acceleration, the best in its class.

The latest official picture of Chery Tiggo 9 is exposed, and the whole series is equipped with 2.0T power

It is reported that the Chery Tiggo 9 new car is positioned as a medium-sized SUV, which will be available in 5-seat and 7-seat versions, and will be fully equipped with a 2.0T engine.

From the latest official picture, Tiggo 9 adopts the latest design style of Tiggo family, which is similar to the Tiggo 7 PLUS currently on sale. The front face is equipped with a large-sized polygonal air intake grille, and the interior of the grille is filled with vertical chrome-plated trims, which brings a strong visual impact while also ensuring a sense of refinement.

The shape of the headlight groups on both sides is relatively narrow and long, composed of strip daytime running lights and matrix-style LED far and near lights, which looks quite high-grade.

The Tiggo 9 is equipped with a through waist line on the side, and the line under the door panel is connected to the wheel eyebrow line, showing a strong sense of power. The C-pillar has been significantly lengthened and blackened. With the 20-inch blackened wheels below, the car looks very powerful.

In terms of power, the Tiggo 9 series will be equipped with Chery Kunpeng Power 2.0TGDI engine, with a maximum power of 187 kW (254 horsepower). In addition to the 7-speed wet dual-clutch transmission, the official also revealed that the Aisin 8AT transmission will be available, and the later plug-in hybrid version will also be launched. In addition, some models are also equipped with a four-wheel drive system, electromagnetic suspension, and wire-controlled brakes.

In terms of body size, the declared length, width and height of the new car are 4820/1930/1699 (1710) mm, and the wheelbase is 2820mm. Five-seat and seven-seat layouts will be available.

III. Vehicle market benefits

"Lifetime quality assurance of all models and vehicles"! Jietu Automobile builds a full-dimensional upgrade of the service system

Driven by a comprehensive upgrade of the service system based on quality, Jietu Automobile officially announced the "lifetime quality assurance of all models and vehicles" policy, starting the first shot of Jietu Automobile’s upward journey in 2023. On the one hand, it highlights Jietu Automobile’s quality confidence, brand confidence, and practices the "user-centered" brand concept; at the same time, it also responds to Chery Group’s vision of breaking industry rules and creating higher quality standards and service levels.

It is understood that this policy will cover the four major brands of Chery Group, Xingtu, Chery, Jietu, and Chery New Energy. Chery Group has also become the first automobile group under the four major brands of China’s mainstream independent automobile brands to implement the policy of "lifetime quality assurance of all models and complete vehicles". It has set a new benchmark for services in the automobile industry and become a pioneer representative of national brands.

Commitment to the policy of "lifetime quality assurance of all models and vehicles" is not only the continuation of the quality gene of Jietu Automobile, but also allows users to buy cars for word-free, save money and worry with cars, and no worries; it is also to further upgrade the ante service experience and scene experience, and help Jietu Automobile win more opportunities for brand improvement in the "Travel +" 2.0 era and achieve longer-term development.

Fourth, the best-selling hot list

Extreme Krypton’s cumulative delivery broke through 80,000 units, and Extreme Krypton 009 started national delivery as scheduled

February 1, 2023, Hangzhou Today, Extreme Krypton Intelligent Technology announced the latest delivery: its luxury hunting coupe Extreme Krypton 001 and native pure electric luxury MPV Extreme Krypton 009 delivered a total of 3,116 units in January. As of now, the cumulative delivery of Extreme Krypton brands has broken through 80,000 units, setting a new record for the fastest delivery of new forces.

From January 11th, the JK Smart Factory stopped production for 21 days due to production line transformation and upgrade. On January 15th, the world’s first native pure electric luxury MPV JK 009 started national delivery. It took only 76 days from listing to delivery, setting another record for the delivery speed of Chinese luxury pure electric brands.

The 2023 Krypton 001 was also newly upgraded in January. With its product strength beyond the same level and the strong systematization strength of Krypton, it was highly recognized by users, and the average order amount exceeded 336,000 yuan. In 2022, Krypton delivered a total of 71,941 units, exceeding the annual delivery target of 70,000 units in advance. With the start of the new year, Krypton will launch two new products, continuously improve the product matrix, create a new market value benchmark, and stand firm in the first echelon of high-end pure electric brands in China. It also put forward the goal of 140,000 units delivered in 2023, and opened a global strategic layout.

Five, today’s model recommendations

Volkswagen, Passat

Price: 18.19-25

Passat is a mid-size B-class sedan designed by Volkswagen AG. Volkswagen Passat sedan has swept the global automobile market with its high standard of safety, classic design and top quality.

Appearance: Body size: car length 4948mm/car width 1836mm/car height 1469mm. In order to better satisfy the aesthetics of young consumers, the overall style of this generation of Passat is still relatively fashionable, especially the star version model, with the new dot matrix grille, it effectively enhances the sense of refinement. At this time, with the front face matrix LED headlight group, as well as the through LED light strip and the luminous brand logo, it can also bring high recognition at any time.

In terms of power and fuel consumption: equipped with a 1.4T 150 horsepower L4 turbocharged engine, the maximum speed is 210km/h, 0-100km/h takes about 9.1S, and the fuel consumption per hundred kilometers is 6.1L.

Advantages: cost-effective, large space, the same level of benchmark.